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- Title
The antimicrobial activity and β-lactamase stability of cefpirorae, a new fourth-generation cephalosporin in comparison with other agents.
- Authors
Cheng, A. F. B.; Ling, T. K. W.; Lam, A. W.; Fung, K. S. C.; Wise, R.
- Abstract
The antimicrobial activity of cefpirome was compared with amoxycillin/clavulanic acid, ampicillin/sulbactam, cefuroxime, ceftazidime, gentamicin and amikacin against 743 non-duplicate clinical isolates. MIC and MIC showed that the antibiotic was active against both Gram-negative and Gram-positive organisms. Cefpirome was highly active against most of the Enterobacteriaceae, including indole-positive Proteus spp., spp. (MIC ≤ 1 mg/L) and spp. (MIC ≤ 0·5 mg/L). and (including -lactamase producers) were all susceptible, with MIC less than 0·5 and 0·25 mg/L respectively. Cefpirome was more active than cefuroxime and ceftazidime against Campylobacter spp. (MIC ≤. 2 mg/L), but less active than ceftazidime against . Cefpirome was active against and coagulase-negative staphylococci (MIC ≤ 0·5 mg/L) and methicillin-sensitive (MIC ≤ 2 mg/L). Methicillin-resistant 5. aureus, Gram-positive and Gram-negative anaerobes were resistant to cefpirome. The stability of cefpirome to TEM-1, TEM-2, PSE-1, SHV-1 and the chromosomal-mediated P99 and K-1 -lactamases was comparable to ceftazidime.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 31, Issue 5, p699
- ISSN
0305-7453
- Publication type
Article