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- Title
AGGRESSIVE BREAST CANCER WITH MULTIPLE DETERMINATIONS AT FIRST ADMISSION -- CASE REPORT.
- Authors
Grosu, Melania-Larisa; Dumitru, Bogdan-Mircea-Călin; Grigorii, Ana-Maria; Tatar, Andrada-Claudia; Sabau, Adrian-Horatiu
- Abstract
Introduction: Breast cancer is a complex and heterogenous disease that affects millions of individuals worldwide, irrespective of age or ethnicity. With numerous subtypes and varying degrees of aggressiveness, breast cancer presents a significant challenge in terms of diagnosis, treatment and management. Case Report: We report the case of a 57-year-old woman who presented to the Surgery Department, accusing breast discomfort, shortness of breath and abdominal pain. A CT was performed and revealed a diffuse infiltrative lesion spread through the right breast and axillary lymph nodes, bilateral pleural effusion, peritoneal carcinomatosis, ascites and bone metastases. A biopsy of the right breast, thoracocentesis and paracentesis was performed and sent to the Pathology Department. Microscopically, an infiltrative tumoral proliferation was identified, corresponding to an invasive lobular breast carcinoma with signet ring cell component, without in situ component. The tumoral cells were immunohistochemically positive for Citokeratin 7, GATA3 and ER. In the pleural and ascites fluid tumoral cells were identified, with marked cyto-nuclear pleomorphism, that were forming pseudo-glandular structures. Immunohistochemically, the tumoral cells were positive for GATA3 and ER markers. Discussions : The immunohistochemical profile of the tumoral cells from pleural effusion and ascites fluids suggest their mammary primary origin. The particularity of the case is emphasized by the fact that the patient is at her first admission and all the specimens collected: breast biopsy, pleural and ascites fluid, all confirmed the presence of malignant cells. In addition to this, the CT scan showed signs of bone metastases and peritoneal carcinomatosis. Conclusions: This case illustrates the importance of interdisciplinary management of the cases with multiple determinations and the weight of immunohistochemistry on correlating all patient's specimens and giving only one diagnosis.
- Subjects
ROMANIA; BREAST tumor diagnosis; BIOPSY; CANCER invasiveness; PATIENTS; HOSPITAL admission &; discharge; CONFERENCES &; conventions; IMMUNOHISTOCHEMISTRY; METASTASIS
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, p319
- ISSN
2668-7755
- Publication type
Article