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- Title
Role of MicroRNAs in Mammalian Reproduction.
- Authors
Shavi; Saini, Sudha; Gupta, Tanya; Selokar, N. L.; Singh, M. K.
- Abstract
MicroRNAs (miRNAs) are small, endogenous, non-coding RNA molecules that are around 19-25 nucleotides long. Most miRNAs are produced via transcription of DNA sequences into primary, precursor, and then mature miRNAs. These miRNAs molecules formed base-pair to mRNAs to post-transcriptionally drive gene expression. There are now over 2000 miRNAs annotated in the mammalian genome, which are thought to affect one-third of the genes, as each miRNA can regulate hundreds of target genes. miRNAs are involved in morphogenesis, tissue maintenance, cell development, differentiation, apoptosis, and metabolism etc. The aim of this review is to summarize the current knowledge on the role of miRNAs in various stages of mammalian reproductive biology and their involvement in reproductive disorders. We have also summarized the recent advances about miRNA and provide an updated overview of the literature, including the most recent and relevant studies.
- Subjects
MICRORNA; MAMMALIAN embryos; DNA sequencing; CHILDBEARING age; APOPTOSIS
- Publication
Animal Reproduction Update, 2023, Vol 3, Issue 2, p33
- ISSN
2583-326X
- Publication type
Article
- DOI
10.48165/aru.2023.3.2.4