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- Title
Cuproptosis: Mechanism, role, and advances in urological malignancies.
- Authors
Wu, Jialong; He, Jide; Liu, Zenan; Zhu, Xuehua; Li, Ziang; Chen, Anjing; Lu, Jian
- Abstract
Prostate, bladder, and kidney cancers are the most common malignancies of the urinary system. Chemotherapeutic drugs are generally used as adjuvant treatment in the middle, late, or recurrence stages after surgery for urologic cancers. However, traditional chemotherapy is plagued by problems such as poor efficacy, severe side effects, and complications. Copper‐containing nanomedicines are promising novel cancer treatment modalities that can potentially overcome these disadvantages. Copper homeostasis and cuproptosis play crucial roles in the development, adaptability, and therapeutic sensitivity of urological malignancies. Cuproptosis refers to the direct binding of copper ions to lipoylated components of the tricarboxylic acid cycle, leading to protein oligomerization, loss of iron–sulfur proteins, proteotoxic stress, and cell death. This review focuses on copper homeostasis and cuproptosis as well as recent findings on copper and cuproptosis in urological malignancies. Furthermore, we highlight the potential therapeutic applications of copper‐ and cuproptosis‐targeted therapies to better understand cuproptosis‐based drugs for the treatment of urological tumors in the future.
- Subjects
KREBS cycle; IRON-sulfur proteins; COPPER; COPPER ions; UROLOGICAL surgery; RENAL cancer; BLADDER cancer
- Publication
Medicinal Research Reviews, 2024, Vol 44, Issue 4, p1662
- ISSN
0198-6325
- Publication type
Article
- DOI
10.1002/med.22025