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- Title
Pacientes jóvenes con CPCNP: Ofrecer siempre un diagnóstico histológico y molecular si se sospecha una neoplasia.
- Authors
Sánchez-Ríos, Carla Paola
- Abstract
Background: We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods: Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlation between EGFR mutation and ALK fusions with clinicopathologic parameters was analyzed. Results: In young NSCLC patients, adenocarcinoma is the major histology (86.9%), and the misdiagnosis rate was as high as 45.7%. EGFR gene mutation was found in 13 patients (31.7%) and common mutations were with EGFR19del mutation (7 cases, 17.1%) and EGFR21L858R mutation (4 patients, 9.7%). EGFR mutation was constantly found in adenocarcinoma and male gender, and ever smokers (100%, P < 0.05). Furthermore, ALK fusions were found in 7 patients (31.8%), which include EML-4-ALK fusions; there was a trend that ALK fusions were associated with adenocarcinoma and female gender. However, there was no significant difference in overall survival between patients with or without gene mutations. Conclusions: EGFR mutation and ALK fusions are related to histology, gender, and smoke exposure in young NSCLC patients, and may be effective predictive factors.
- Subjects
GENETIC mutation; GENETIC correlations; OVERALL survival; EPIDERMAL growth factor receptors; CIRCULATING tumor DNA
- Publication
Kompass Neumología, 2022, Vol 4, Issue 3, p154
- ISSN
2624-9065
- Publication type
Article
- DOI
10.1159/000527242