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- Title
Synthese der Sequenz 1-34 von menschlichem Parathormon. Vorläufige Mitteilung.
- Authors
Andreatta, R. H.; Hartmann, A.; Jöhl, A.; Kamber, B.; Maier, R.; Riniker, B.; Rittel, W.; Sieber, P.
- Abstract
Brewer et al. [1] have established sequence I for the first 34 amino acid residues of human parathyroid hormone. It differs in 6 and 5 positions respectively from the corresponding bovine [2] [3] and porcine [4] hormone sequences. The synthesis of the protected tetratriacontapeptide II by the fragment-coupling approach and its purification by counter-current distribution are described. Removal of the protecting groups by acidolysis then gave I in high purity. I displays hypercalcemic activity in the thyroparathyroidectomized rat indicating that the amino terminal part also constitutes the hormonally active region of human parathyroid hormone.
- Publication
Helvetica Chimica Acta, 1973, Vol 56, Issue 1, p470
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19730560139