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- Title
Quinazolines et benzodiazépines-1, 4. LVI. Oxadiazolo-1, 2, 4[4, 5-d] benzodiazépines-1, 4: synthése et passage aux oxazolo [3, 2-d] benzodiazépines-1, 4.
- Authors
Jaunin, R.; Oberhänsli, W. E.; Hellerbach, J.
- Abstract
The tricyclic derivatives 4-14 can be prepared by 1, 3-dipolarcycloaddition of the appropriate nitrile oxides on the corresponding 1, 4-benzodiazepines. NaBH4 reduction of the esters 12-14 was found to proceed very readily; starting from 13 it is possible, by proper reaction conditions, to get in good yield either the monoalcohol 19 or the aminodiol 20. The alcohols 19 and 23 undergo an acid-catalysed rearrangement which produces the amidoximes 24 and 26. The determination of the structure of 24 by X-ray diffraction analysis is also presented.
- Publication
Helvetica Chimica Acta, 1972, Vol 55, Issue 8, p2975
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19720550831