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- Title
HLA antibody screening in kidney transplantation: current guidelines.
- Authors
Wettstein, Dániel; Opelz, Gerhard; Süsal, Caner
- Abstract
Background: In organ transplantation, the introduction of the solid phase immunoassay technology radically changed the practice of antibody monitoring against human leukocyte antigens (HLA). Purpose: Precise identification of antibody specificities in complex sera of sensitized patients and monitoring of low levels of donor-specific HLA antibodies in the posttransplant phase became possible. However, at the same time, new technical problems and great variation emerged in the interpretation of test results, indicating a need for standardization. Conclusion: In May 2012, The Transplantation Society (TTS) recruited a panel of laboratory and clinical experts to discuss emerging testing and clinical management issues that are associated with antibody testing in organ transplantation. In this article, we provide a summary of the TTS recommendations formulated in this international effort on the standardization of antibody monitoring in kidney transplantation.
- Subjects
HLA histocompatibility antigens; IMMUNOGLOBULINS; MEDICAL screening; KIDNEY transplantation; GUIDELINES
- Publication
Langenbeck's Archives of Surgery, 2014, Vol 399, Issue 4, p415
- ISSN
1435-2443
- Publication type
Article
- DOI
10.1007/s00423-013-1138-6