We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The SYK tyrosine kinase: a crucial player in diverse biological functions.
- Authors
Mócsai, Attila; Ruland, Jürgen; Tybulewicz, Victor L. J.; Mócsai, Attila; Ruland, Jürgen
- Abstract
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.
- Subjects
SPLEEN; PROTEIN-tyrosine kinases; CELL adhesion; IMMUNE recognition; OSTEOCLASTS; BLOOD platelet activation; LECTINS; AUTOIMMUNE diseases; CELL differentiation; CELL physiology; CELL receptors; CELLULAR signal transduction; RESEARCH funding; SIGNAL peptides
- Publication
Nature Reviews Immunology, 2010, Vol 10, Issue 6, p387
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2765