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- Title
EMERGING LINKS BETWEEN HYPERMUTATION OF ANTIBODY GENES AND DNA POLYMERASES.
- Authors
Gearhart, Patricia J.; Wood, Richard D.
- Abstract
Substantial antibody variability is created when nucleotide substitutions are introduced into immunoglobulin variable genes by a controlled process of hypermutation. Evidence points to a mechanism involving DNA repair events at sites of targeted breaks. In vertebrate cells, there are many recently identified DNA polymerases that inaccurately copy templates. Some of these are candidates for enzymes that introduce base changes during hypermutation. Recent research has focused on possible roles for DNA polymerases ζ (POLZ), η (POLH), ι (POLI), and μ (POLM) in the process.
- Subjects
IMMUNOGLOBULINS; GENETIC mutation; DNA repair; BIOCHEMICAL genetics; DNA polymerases
- Publication
Nature Reviews Immunology, 2001, Vol 1, Issue 3, p187
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/35105009