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- Title
Profil Hematologi dan Kadar Mineral Darah Tikus Putih pada Implantasi Bone Filler Produk Lokal.
- Authors
Putri, Nadya Amanda; Gunanti; Gustiono, Dwi; Santosa Wargadipura, Agus Hadi; Noviana, Deni
- Abstract
Hydroxyapatite and beta tricalcium phosphate are one of the biomaterials used in denstistry and orthopedics for grafting because of its compatiblity with human’s body. Increasing demand for bone graft brings our country to develop local bone filler that is cheaper, easy to access, and biocompatible to be used. The objective of this research was to identify locally made bone filler’s hemocompatibility by evaluating blood profile and mineral serum levels. Twenty-eight Sprague Dawley rats were used in this experiment and divided into four groups. Group I as the control, group II was implanted with commercial bone graft, group III and IV with porous and granule type of local bone fillers developed by Agency for the Assessment and Application of Technology (BPPT). Each group received a circular 5 mm defect in calvaria bone and was taken the blood after 30 days. Parameters taken for blood profiles were red blood cells, white blood cells, and mineral serum calcium and phosphate. There were no signs of significance red blood profile’s changes (P>0.05) with erythrocyte ranging from 4.50-4.83x10³μL although the amount of thrombocyte was slightly elevated in porous and granul groups post implantation, and on white blood profile’s changes (P>0.05) with leucocyte ranging from 7.74-9.14x10³μL. This research showed that locally made bone graft did not inflict chronic inflammation and was hemobiocompatible.
- Publication
Jurnal Veteriner, 2020, Vol 21, Issue 3, p382
- ISSN
1411-8327
- Publication type
Article
- DOI
10.19087/jveteriner.2020.21.3.382