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- Title
Increased Cardiovascular Stiffness and Impaired Age-related Functional Status.
- Authors
Andersen, Mousumi M.; Kritchevsky, Stephen B.; Morgan, Timothy M.; Hire, Don G.; Vasu, Sujethra; Brinkley, Tina E.; Kitzman, Dalane W.; Hamilton, Craig A.; Soots, Sandra; Hundley, William G.
- Abstract
Our objective was to determine if increased cardiovascular (CV) stiffness is associated with disability in middle-aged and older adults at risk for congestive heart failure. CV stiffness (brachial pulse pressure/left ventricular stroke volume indexed to body surface area) and total disability (the summed assessment of activities of daily living, mobility, and instrumental activities of daily living) were measured in 445 individuals. A subset of 109 randomly selected individuals also underwent physical function testing. Total disability was associated with CV stiffness (p = .01), driven by an association with mobility (p = .005), but not activities of daily living (p = .13) or instrumental activities of daily living (p = .61). After accounting for age, these correlations remained significant for men (p = .04), but not for women. CV stiffness was also associated with increased 400-m walk time (p= .02). In middle-aged and elderly men at risk for congestive heart failure, CV stiffness is associated with decreased mobility and physical function, and increased overall disability.
- Subjects
CARDIOVASCULAR diseases; AGE factors in disabilities; DISEASES in older people; ARTERIAL diseases; CONGESTIVE heart failure
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2015, Vol 70, Issue 5, p545
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glu085