The article describes a new target of suppressor of cytokine signaling 1 (SOCS-1)-mediated negative regulation. SOCS-1 is needed for the rapid degradation of Mal, an adaptor protein involved in TLR2 and TLR4 signaling. It is induced by toll-like receptor ligand stimulation in macrophages. Unknown target of SOCS-1 in TLR signaling has been identified.