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- Title
A continuous-flow procedure for the synthesis of 4-Benzylidene-pyrazol-5-one derivatives.
- Authors
Yu, Jiangang; Xu, Jianguo; Li, Jie; Jin, Yi; Xu, Wanghui; Yu, Zhiqun; Lv, Yanwen
- Abstract
A two-step flow reactor has been set up for an expeditious synthesis of 4-benzylidene-pyrazol-5-one derivatives. This procedure involved cyclization of aromatic hydrazine/<italic>β</italic>-keto ester and subsequent Knoevenagel condensation reaction with aromatic aldehydes in tandem without isolation of intermediates. Residence time was reduced to less than 2 min in total through conducting this reaction at a relatively high temperature. Accordingly, 15 samples were achieved and isolated in moderate to excellent yields.ᅟ<graphic></graphic>
- Subjects
BENZYLIDENE compounds; BENZENE synthesis; CONTINUOUS flow reactors; RING formation (Chemistry); PHENYLHYDRAZINE
- Publication
Journal of Flow Chemistry, 2018, Vol 8, Issue 1, p29
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-018-0003-8