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- Title
トウゲシバ (Huperzia serrata) 関連製品の流通実態調査.
- Authors
田中誠司; 辻本恭; 小関良宏; 袴塚高志; 内山奈穂子
- Abstract
The crude drug "Sensoutou" is derived from a whole plant of the toothed clubmoss (Huperzia serrata). In 2021, "Sensoutou" was classified as "raw materials used as non-pharmaceuticals" in Japan and health food products, such as dietary supplements derived from toothed clubmoss, are sold commercially. Huperzine A, an alkaloid isolated from H. serrata, inhibits acetylcholinesterase and is expected to be a therapeutic agent for Alzheimer's disease. However, there have been reports of health problems caused by foods containing Huperzine A. This study conducted qualitative and quantitative analyses using UHPLC-PDA-MS on 13 health food products related to toothed clubmoss. Qualitative analysis showed that Huperzine A was detected in 10 of the 13 samples. The maximum daily intake of Huperzine A calculated from the results of the quantitative study was between 7.83 and 691.68 µg/day. These products derived from toothed clubmoss may have health risks because the acceptable daily intake of Huperzine A calculated from a previous toxicity study was 3.03 µg/day. Incidentally, in Japan, "Sensoutou" was reclassified from "raw materials used as nonpharmaceuticals" to "raw materials exclusively used as pharmaceuticals" on February 25, 2022.
- Publication
Japanese Journal of Food Chemistry & Safety, 2022, Vol 29, Issue 3, p184
- ISSN
1341-2094
- Publication type
Article