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- Title
Apoptosis induced by the esters of picolinic acid with alkyl groups in HL-60 cells.
- Authors
Shin Ogata; Kazuko Inoue; Chieri Ida; Katsuzumi Okumura
- Abstract
We have previously found that picolinic acid and its related compounds can induce apoptosis in human promyelocytic leukemia (HL-60) cells, but not at <2 mM concentration. In the present study, we examined whether different esters of picolinic acid with alkyl groups and those with cholesterol can induce apoptosis. We found that the esters of picolinic acid with octyl, decyl, dodecyl, and hexadecyl groups induced apoptosis in HL-60 cells most effectively in a chain length-dependent manner. Particularly, dodecyl picolinate induced apoptosis even at over 0.01 mM concentration. On the other hand, cholesteryl picolinate did not induce apoptosis. In addition, we examined the effect of vitamin E as an antioxidant on apoptosis induced by picolinic acid or various esters of picolinic acid in HL-60 cells. We found that percent of sub-G1 peak was more effectively decreased by pre-treatment with vitamin E. Cumulatively, our results suggest that the apoptosis induced by esterification of the carboxyl group of picolinic acid with various alkyl groups is more effective.
- Subjects
APOPTOSIS; ESTERS; PICOLINIC acid; ALKYL group; CARBOXYL group
- Publication
Japanese Journal of Food Chemistry & Safety, 2018, Vol 25, Issue 3, p114
- ISSN
1341-2094
- Publication type
Article