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- Title
Association of the hsa-mir-499 (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population.
- Authors
Wu, Xiao-Jin; Mi, Yan-Yan; Yang, Hui; Hu, an-Kang; Li, Chen; Li, Xiao-Dong; Zhang, Qing-Guo
- Abstract
Background: Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population. Patients and Methods: The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes. Conclusion: The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.
- Publication
Oncology Research & Treatment, 2013, Vol 36, Issue 10, p573
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000355518