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- Title
Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection.
- Authors
Elliott, Eric I; Smith, Daisy; Lipscomb, Jonathan; Banini, Bubu; Meurer, Lindsay; Vanderford, Thomas H; Johnson, Jeffrey A; Jain, Dhanpat; Achhra, Amit
- Abstract
The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.
- Subjects
HIV infections; PRIMARY immunodeficiency diseases; HIV; CHRONIC active hepatitis; HEPATITIS
- Publication
Open Forum Infectious Diseases, 2024, Vol 11, Issue 4, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofae170