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Whole-Exome Sequencing of an Exceptional Longevity Cohort.
Published in:
2019
By:
- Nygaard, Haakon B;
- Erson-Omay, E Zeynep;
- Wu, Xiujuan;
- Kent, Brianne A;
- Bernales, Cecily Q;
- Evans, Daniel M;
- Farrer, Matthew J;
- Vilariño-Güell, Carles;
- Strittmatter, Stephen M
Publication type:
journal article
Scalable Multi‐Sensor At Home Assessment of Sleep and Activity in Adults At High Risk for Dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076469
By:
- Lim, Andrew;
- Centen, Andrew Peter;
- Montazeri, Nasim;
- Gibson, Erin;
- Dang‐Vu, Thien Thanh;
- Carrier, Julie;
- Chan, Senny;
- Belleville, Sylvie;
- Nygaard, Haakon B.;
- Montero‐Odasso, Manuel;
- Feldman, Howard H.;
- Chertkow, Howard
Publication type:
Article
CAN‐THUMBS UP: Recruitment in the Virtual Era.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075155
By:
- Nygaard, Haakon B.;
- Slack, Penelope;
- Feldman, Howard H.;
- Chertkow, Howard;
- Belleville, Sylvie;
- Montero‐Odasso, Manuel;
- Anderson, Nicole D.;
- Bennett, Daniel;
- Borrie, Michael;
- Chan, Senny;
- Jarrett, Pamela;
- Lee, Ashley;
- Lupo, Jody‐Lynn;
- Matthews, Genevieve;
- McGibbon, Chris A;
- Revta, Carolyn;
- Robillard, Julie M.;
- Shadyab, Alexandre;
- Shajan, Sheetal
Publication type:
Article
Virtual Cognitive Testing‐ Neuropsychology, MyCogHealth and Cogniciti.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075157
By:
- Brewster, Paul;
- Hofer, Scott M;
- Jacobs, Diane M.;
- Feldman, Howard H.;
- Belleville, Sylvie;
- Montero‐Odasso, Manuel;
- Nygaard, Haakon B.;
- Chertkow, Howard
Publication type:
Article
Brain Health PRO: An Interactive, Online, Educational Program for Dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075156
By:
- Belleville, Sylvie;
- Chertkow, Howard;
- Feldman, Howard H.;
- Nygaard, Haakon B.;
- Montero‐Odasso, Manuel;
- Anderson, Nicole D.;
- Bherer, Louis;
- Ferland, Guylaine;
- Camicioli, Richard;
- Chan, Senny;
- Cuesta, Marc;
- Dwosh, Emily;
- Fiocco, Alexandra J;
- Gilbert, Brigitte;
- Itzhak, Inbal;
- Jarrett, Pamela;
- Laurin, Danielle;
- Liu‐Ambrose, Teresa;
- Lupo, Jody‐Lynn;
- McGibbon, Chris A
Publication type:
Article
Virtual Design of the Brain Health Support Program and CAN‐THUMBS UP.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075153
By:
- Feldman, Howard H.;
- Belleville, Sylvie;
- Nygaard, Haakon B.;
- Montero‐Odasso, Manuel;
- Chertkow, Howard
Publication type:
Article
Characterization of a R493X progranulin haploinsufficient knockin mouse model of frontotemporal dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078035
By:
- Cai, Wenji;
- Nygaard, Haakon B.;
- Wendt, Stefan;
- Sorrentino, Stefano
Publication type:
Article
Characterization of a R493X progranulin haploinsufficient knockin mouse model of frontotemporal dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078035
By:
- Cai, Wenji;
- Nygaard, Haakon B.;
- Wendt, Stefan;
- Sorrentino, Stefano
Publication type:
Article
Drug therapy, imaging, and other aspects of clinical management change after Alzheimer's biomarker testing in routine practice: Findings from the IMPACT‐AD BC study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.069439
By:
- Yang, David;
- Best, John R.;
- Chambers, Colleen;
- Feldman, Howard H.;
- Pettersen, Jacqueline A;
- Henri‐Bhargava, Alexander;
- Lee, Philip E;
- Nygaard, Haakon B.;
- Funnell, Clark R;
- Foti, Dean J;
- Hsiung, Ging‐Yuek Robin;
- DeMarco, Mari L.
Publication type:
Article
What patients and caregivers do with knowledge of Alzheimer's disease CSF test results: Findings from the IMPACT‐AD BC study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.068306
By:
- Patel, Khushbu Jayeshkumar;
- Yang, David;
- Chambers, Colleen;
- Feldman, Howard H.;
- Hsiung, Ging‐Yuek Robin;
- Nygaard, Haakon B.;
- Best, John R.;
- Dwosh, Emily;
- Robillard, Julie M.;
- DeMarco, Mari L.
Publication type:
Article
The SYNERGIC RCTs from Can Thumbs Up: Canadian experience in migrating lifestyle interventions to an @Home‐based program to enhance cognition.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055806
By:
- Montero‐Odasso, Manuel;
- Jarrett, Pamela;
- Handrigan, Grant;
- Chamard‐Witkowski, Ludivine;
- Bouchard, Danielle R;
- Tranchant, Carole C;
- Yetman, Linda;
- Belleville, Sylvie;
- Chertkow, Howard;
- Feldman, Howard;
- Nygaard, Haakon B;
- Almeida, Quincy J;
- Bherer, Louis;
- Liu‐Ambrose, Teresa;
- Middleton, Laura E;
- Speechley, Mark R;
- Kamkar, Nellie;
- McGibbon, Chris A
Publication type:
Article
Differentiating memory clinic patients and healthy volunteers using machine‐learning analysis of speech and eye movements during a reading task.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055717
By:
- Soroski, Thomas;
- Barral, Oswald;
- Jang, Hyeju;
- Newton‐Mason, Sally May;
- Shajan, Sheetal;
- Tutt, Pavan;
- Granby, Saffrin;
- Rizzo, Matteo;
- Chui, Diego;
- Teng, Minnie Y;
- Chatterjee, Atri;
- Hsiung, Ging‐Yuek Robin;
- Nygaard, Haakon B.;
- Conati, Cristina;
- Carenini, Giuseppe;
- Field, Thalia S.
Publication type:
Article
CAN‐Thumbs UP (Canada): World‐Wide FINGERS network: The first global network of multidomain dementia prevention trials.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046952
By:
- Nygaard, Haakon B.;
- Chertkow, Howard;
- Feldman, Howard H.;
- Belleville, Sylvie;
- Montero‐Odasso, Manuel
Publication type:
Article
The Brain Health Support Program: A web‐based interactive platform to increase dementia literacy and awareness regarding lifestyle factors in at‐risk individuals: Advancing clinical trial design and methods in a digital age.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042603
By:
- Belleville, Sylvie;
- Nygaard, Haakon B;
- Bherer, Louis;
- Camicioli, Richard;
- Carrier, Julie;
- Anderson, Nicole D;
- Dang‐Vu, Thien Thanh;
- Dwosh, Emily;
- Ferland, Guylaine;
- Harris, Elaine;
- Laurin, Danielle;
- Liu‐Ambrose, Teresa;
- Madlensky, Lisa;
- Miller, Lesley;
- Montero‐Odasso, Manuel;
- Phillips, Natalie;
- Pichora‐Fuller, M Kathleen;
- Robillard, Julie;
- Smith, Eric E;
- Speechley, Mark R
Publication type:
Article
Intensive measurement of cognition to support early detection of cognitive change in individuals at risk of dementia: Advancing clinical trial design and methods in a digital age.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042599
By:
- Brewster, Paul;
- Rush, Jonathan;
- Ozen, Lana;
- Jacobs, Diane M;
- Kaye, Jeffrey;
- Nygaard, Haakon B;
- Feldman, Howard H;
- Hofer, Scott M
Publication type:
Article
A phase 1B multiple ascending dose study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of a medium chain triglyceride supplement in Alzheimer's disease: Brain energy rescue interventions to treat or delay Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.037960
By:
- Nygaard, Haakon B;
- Kent, Brianne A;
- Stager, Sam;
- Slack, Penelope;
- DeMarco, Mari L;
- Castellano, Christian‐Alexandre;
- Rauscher, Alexander;
- Cunnane, Stephen;
- Feldman, Howard H
Publication type:
Article
O3‐01‐02: CHIMERA REPETITIVE MILD TRAUMATIC BRAIN INJURY INDUCES CHRONIC BEHAVIORAL AND NEUROPATHOLOGICAL PHENOTYPES IN WILD‐TYPE AND APP/PS1 MICE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P875, doi. 10.1016/j.jalz.2019.06.4625
By:
- Cheng, Wai Hang;
- Martens, Kris M.;
- Bashir, Asma;
- Cheung, Honor;
- Stukas, Sophie K.;
- Gibbs, Ebrima;
- Namjoshi, Dhananjay;
- Button, Emily B.;
- Wilkinson, Anna;
- Barron, Carlos J.;
- Kent, Brianne A.;
- Nygaard, Haakon B.;
- Cashman, Neil R.;
- Cripton, Peter A.;
- Wellington, Cheryl L.
Publication type:
Article
P1‐137: CLINICAL DETAILS OF THE ILE213LEU PSEN1 MUTATION IN A FAMILY WITH EARLY ONSET FAMILIAL ALZHEIMER DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P289, doi. 10.1016/j.jalz.2019.06.692
By:
- Funnell, Clark R.;
- Dwosh, Emily;
- Nygaard, Haakon B.
Publication type:
Article
PHARMACOKINETICS AND DYNAMICS OF A KETOGENIC INTERVENTION IN ALZHEIMER'S DISEASE AND FRONTOTEMPORAL DEMENTIA.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P883, doi. 10.1016/j.jalz.2017.07.276
By:
- Nygaard, Haakon B.
Publication type:
Article
EVALUATION OF CIRCADIAN RHYTHMS AND SLEEP IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1031, doi. 10.1016/j.jalz.2016.06.2134
By:
- Kent, Brianne A.;
- Michalik, Mateusz;
- Feldman, Howard H.;
- Mistlberger, Ralph E.;
- Nygaard, Haakon B.
Publication type:
Article
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 18, p. 6367, doi. 10.1523/JNEUROSCI.0395-10.2010
By:
- Gimbel, David A.;
- Nygaard, Haakon B.;
- Coffey, Erin E.;
- Gunther, Erik C.;
- Laurén, Juha;
- Gimbel, Zachary A.;
- Strittmatter, Stephen M.
Publication type:
Article
Laurén et al. reply.
Published in:
Nature, 2010, v. 466, n. 7308, p. E4, doi. 10.1038/nature09218
By:
- Laurén, Juha;
- Gimbel, David A.;
- Nygaard, Haakon B.;
- Gilbert, John W.;
- Strittmatter, Stephen M.
Publication type:
Article
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers.
Published in:
2009
By:
- Laurén, Juha;
- Gimbel, David A.;
- Nygaard, Haakon B.;
- Gilbert, John W.;
- Strittmatter, Stephen M.
Publication type:
Letter
Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.
Published in:
JAMA Neurology, 2019, v. 76, n. 10, p. 1219, doi. 10.1001/jamaneurol.2019.2050
By:
- van Dyck, Christopher H.;
- Nygaard, Haakon B.;
- Chen, Kewei;
- Donohue, Michael C.;
- Raman, Rema;
- Rissman, Robert A.;
- Brewer, James B.;
- Koeppe, Robert A.;
- Chow, Tiffany W.;
- Rafii, Michael S.;
- Gessert, Devon;
- Choi, Jiyoon;
- Turner, R. Scott;
- Kaye, Jeffrey A.;
- Gale, Seth A.;
- Reiman, Eric M.;
- Aisen, Paul S.;
- Strittmatter, Stephen M.
Publication type:
Article
A Deep Learning Strategy for Automatic Sleep Staging Based on Two-Channel EEG Headband Data.
Published in:
Sensors (14248220), 2021, v. 21, n. 10, p. 3316, doi. 10.3390/s21103316
By:
- Casciola, Amelia A.;
- Carlucci, Sebastiano K.;
- Kent, Brianne A.;
- Punch, Amanda M.;
- Muszynski, Michael A.;
- Zhou, Daniel;
- Kazemi, Alireza;
- Mirian, Maryam S.;
- Valerio, Jason;
- McKeown, Martin J.;
- Nygaard, Haakon B.;
- Lee, Jinseok
Publication type:
Article
Community participation in activities and places among older adults with and without dementia.
Published in:
Dementia (14713012), 2021, v. 20, n. 4, p. 1213, doi. 10.1177/1471301220927230
By:
- Chaudhury, Habib;
- Mahal, Tanveer;
- Seetharaman, Kishore;
- Nygaard, Haakon B.
Publication type:
Article
Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.
Published in:
Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0110-9
By:
- Nygaard, Haakon B.;
- Kaufman, Adam C.;
- Sekine-Konno, Tomoko;
- Huh, Linda L.;
- Going, Hilary;
- Feldman, Samantha J.;
- Kostylev, Mikhail A.;
- Strittmatter, Stephen M.
Publication type:
Article
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.
Published in:
Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0119-0
By:
- Nygaard, Haakon B.;
- Wagner, Allison F.;
- Bowen, Garrett S.;
- Good, Susan P.;
- MacAvoy, Martha G.;
- Strittmatter, Kurt A.;
- Kaufman, Adam C.;
- Rosenberg, Brian J.;
- Tomoko Sekine-Konno;
- Varma, Pradeep;
- Kewei Chen;
- Koleske, Anthony J.;
- Reiman, Eric M.;
- Strittmatter, Stephen M.;
- van Dyck, Christopher H.
Publication type:
Article
Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.
Published in:
Journal of Comparative Neurology, 2013, v. 521, n. 6, p. 1395, doi. 10.1002/cne.23239
By:
- Couch, Brian A.;
- Kerrisk, Meghan E.;
- Kaufman, Adam C.;
- Nygaard, Haakon B.;
- Strittmatter, Stephen M.;
- Koleske, Anthony J.
Publication type:
Article
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Published in:
Annals of Neurology, 2015, v. 77, n. 6, p. 953, doi. 10.1002/ana.24394
By:
- Kaufman, Adam C.;
- Salazar, Santiago V.;
- Haas, Laura T.;
- Yang, Jinhee;
- Kostylev, Mikhail A.;
- Jeng, Amanda T.;
- Robinson, Sophie A.;
- Gunther, Erik C.;
- van Dyck, Christopher H.;
- Nygaard, Haakon B.;
- Strittmatter, Stephen M.
Publication type:
Article
A Novel Presenilin 1 Mutation in Early-Onset Alzheimer’s Disease With Prominent Frontal Features.
Published in:
2014
By:
- Nygaard, Haakon B.;
- Lippa, Carol F.;
- Mehdi, Djekidel;
- Baehring, Joachim M.
Publication type:
Journal Article
A Novel Presenilin 1 Mutation in Early-Onset Alzheimer’s Disease With Prominent Frontal Features.
Published in:
American Journal of Alzheimer's Disease & Other Dementias, 2014, v. 29, n. 5, p. 433, doi. 10.1177/1533317513518653
By:
- Nygaard, Haakon B.;
- Lippa, Carol F.;
- Mehdi, Djekidel;
- Baehring, Joachim M.
Publication type:
Article
Clinical value of Alzheimer's disease biomarker testing.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024, v. 10, n. 2, p. 1, doi. 10.1002/trc2.12464
By:
- Patel, Khushbu J.;
- Yang, David;
- Best, John R.;
- Chambers, Colleen;
- Lee, Philip E.;
- Henri‐Bhargava, Alexandre;
- Funnell, Clark R.;
- Foti, Dean J.;
- Pettersen, Jacqueline A.;
- Feldman, Howard H.;
- Nygaard, Haakon B.;
- Hsiung, Ging‐Yuek R.;
- DeMarco, Mari L.
Publication type:
Article
Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024, v. 10, n. 2, p. 1, doi. 10.1002/trc2.12463
By:
- Patel, Khushbu J.;
- Yang, David;
- Feldman, Howard H.;
- Hsiung, Ging‐Yuek R.;
- Nygaard, Haakon B.;
- Best, John R.;
- Dwosh, Emily;
- Robillard, Julie M.;
- DeMarco, Mari L.
Publication type:
Article
Home EEG sleep assessment shows reduced slow-wave sleep in mild-moderate Alzheimer's disease.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, v. 8, n. 1, p. 1, doi. 10.1002/trc2.12347
By:
- Kent, Brianne A.;
- Casciola, Amelia A.;
- Carlucci, Sebastiano K.;
- Chen, Meghan;
- Stager, Sam;
- Mirian, Maryam S.;
- Slack, Penelope;
- Valerio, Jason;
- McKeown, Martin J.;
- Feldman, Howard H.;
- Nygaard, Haakon B.
Publication type:
Article
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
Published in:
Nature Neuroscience, 2012, v. 15, n. 9, p. 1227, doi. 10.1038/nn.3178
By:
- Um, Ji Won;
- Nygaard, Haakon B;
- Heiss, Jacqueline K;
- Kostylev, Mikhail A;
- Stagi, Massimiliano;
- Vortmeyer, Alexander;
- Wisniewski, Thomas;
- Gunther, Erik C;
- Strittmatter, Stephen M
Publication type:
Article
Multidomain trials to prevent dementia: addressing methodological challenges.
Published in:
Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01036-1
By:
- Montero-Odasso, Manuel;
- Zou, G Y;
- Kamkar, Nellie;
- Feldman, Howard H.;
- Belleville, Sylvie;
- Chertkow, Howard;
- Nygaard, Haakon B;
- Son, Surim;
- Speechley, Mark
Publication type:
Article
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.
Published in:
Molecular Neurodegeneration, 2020, v. 15, n. 1, p. 1, doi. 10.1186/s13024-020-00369-5
By:
- Frew, Jonathan;
- Baradaran-Heravi, Alireza;
- Balgi, Aruna D.;
- Wu, Xiujuan;
- Yan, Tyler D.;
- Arns, Steve;
- Shidmoossavee, Fahimeh S.;
- Tan, Jason;
- Jaquith, James B.;
- Jansen-West, Karen R.;
- Lynn, Francis C.;
- Gao, Fen-Biao;
- Petrucelli, Leonard;
- Feldman, Howard H.;
- Mackenzie, Ian R.;
- Roberge, Michel;
- Nygaard, Haakon B.
Publication type:
Article

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