We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome.
- Authors
Mori, Hiroshi; Tomiyama, Takami; Maeda, Naoki; Ozawa, Kazuharu; Wakasa, KenIchi
- Abstract
Werner syndrome (WS) is an autosomal recessive disorder associated with accelerated aging. It is well documented on systemic aging but it is unclear whether the brain with WS shows accelerated aging. A 55-year-old patient with WS was studied and it was found that a deletion mutation of exon 26 of the WRN gene was not associated with CNS pathology, such as amyloid plaques or NFT. Furthermore, additional genetic analysis showed an apolipoprotein E genotype of ℇ3/ℇ3 that did not play either an accelerating or inhibitory action on amyloid deposition. Therefore, based on the genetic and neuropathological analysis, it was observed that the WS-associated aging seen in many organs did not extend to the CNS.
- Subjects
WERNER'S syndrome; AMYLOID; AGING; CENTRAL nervous system
- Publication
Neuropathology, 2003, Vol 23, Issue 1, p51
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1046/j.1440-1789.2003.00474.x