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- Title
Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: efficacy in preoperative grading.
- Authors
Yu-Chuan Hu; Lin-Feng Yan; Lang Wu; Pang Du; Bao-Ying Chen; Liang Wang; Shu-Mei Wang; Yu Han; Qiang Tian; Ying Yu; Tian-Yong Xu; Wen Wang; Guang-Bin Cui
- Abstract
The preoperative grading of gliomas, which is critical for guiding therapeutic strategies, remains unsatisfactory. We aimed to retrospectively assess the efficacy of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the grading of gliomas. Forty-two newly diagnosed glioma patients underwent conventional MR imaging, DWI, and contrast-enhanced MR imaging. Parameters of apparent diffusion coefficient (ADC), slow diffusion coefficient (D), fast diffusion coefficient (D*), and fraction of fast ADC(f) were generated. They were tested for differences between low- and high-grade gliomas based on one-way ANOVA. Receiver-operating characteristic (ROC) analyses were conducted to determine the optimal thresholds as well as the sensitivity and specificity for grading. ADC, D, and f were higher in the low-grade gliomas, whereas D* tended to be lower (all P,0.05). The AUC, sensitivity, specificity and the cutoff value, respectively, for differentiating low- from high-grade gliomas for ADC, D and f, and differentiating high- from low-grade gliomas for D* were as follows: ADC, 0.926, 100%, 82.8%, and 0.7 3×10-3 mm2/sec; D, 0.942, 92.3%, 86.2%, and 0.623 3×10-3 mm2/sec; f, 0.902, 92.3%, 86.2%, and 35.3%; D*, 0.798, 79.3%, 84.6%, and 0.303310 -3 mm2/sec. The IVIMDWIdemonstrates efficacy in differentiating the low- from high-grade gliomas.
- Subjects
MAGNETIC resonance imaging; GLIOMAS; PREOPERATIVE care; ANALYSIS of variance; DIFFUSION coefficients; RECEIVER operating characteristic curves; DIAGNOSIS
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep07208