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- Title
CAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option.
- Authors
Műzes, Györgyi; Sipos, Ferenc
- Abstract
The pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediated diseases. By doing so, they can contribute to an effective and relatively long-lasting remission. In turn, CAR Treg interventions may have a highly effective and durable immunomodulatory effect via a direct or bystander effect, which may have a positive impact on the course and prognosis of autoimmune diseases. CAR-based cellular techniques have a complex theoretical foundation and are difficult to implement in practice, but they have a remarkable capacity to suppress the destructive functions of the immune system. This article provides an overview of the numerous CAR-based therapeutic options developed for the treatment of immune-mediated and autoimmune diseases. We believe that well-designed, rigorously tested cellular therapies could provide a promising new personalized treatment strategy for a significant number of patients with immune-mediated disorders.
- Subjects
AUTOIMMUNE diseases; T cells; CHIMERIC antigen receptors; PROGNOSIS; T cell receptors; THERAPEUTICS; CELLULAR therapy
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 11, p1534
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12111534