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Revisiting the genomic hypomethylation hypothesis of aging.
Published in:
Annals of the New York Academy of Sciences, 2018, v. 1418, n. 1, p. 69, doi. 10.1111/nyas.13533
By:
- Unnikrishnan, Archana;
- Hadad, Niran;
- Masser, Dustin R.;
- Jackson, Jordan;
- Freeman, Willard M.;
- Richardson, Arlan
Publication type:
Article
Not all regions are created equal: identifying regions and cell types associated with cognitive resilience in the AD‐BXD model population.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082599
By:
- Gurdon, Brianna;
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Murdy, Thomas J;
- Yates, Sharon;
- Puchades, Maja Amedjkouh;
- Bjaalie, Jan;
- Kaczorowski, Catherine C.
Publication type:
Article
Investigating Dendritic Spine Morphology as a Mediator of Cognitive Outcomes in Aged Diversity Outbred Mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079832
By:
- Ouellette, Andrew R;
- Herskowitz, Jeremy H;
- Greathouse, Kelsey M;
- Weber, Audrey J;
- Hadad, Niran;
- Kaczorowski, Catherine C.
Publication type:
Article
Early synaptic gene expression downregulation in the frontal cortex distinguishes Alzheimer's disease from normal aging in a genetically diverse mouse population.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065931
By:
- Dunn, Amy R;
- Ouellette, Andrew R;
- Hadad, Niran;
- Zhang, Jigang;
- Philip, Vivek M.;
- O'Connell, Kristen;
- Kaczorowski, Catherine C.
Publication type:
Article
Identification of Genetic Loci and Sex Differences Associated with Amyloid Burden Using the AD‐BXD Mouse Population.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069391
By:
- Charland, Kevin;
- Kaur, Harpreet;
- Hadad, Niran;
- Ouellette, Andrew R;
- O'Connell, Kristen MS;
- Kaczorowski, Catherine C.
Publication type:
Article
Conserved cell‐type specific signature of resilience to Alzheimer's disease nominates role for excitatory cortical neurons.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069370
By:
- Telpoukhovskaia, Maria;
- Hadad, Niran;
- Gurdon, Brianna;
- Dai, Miko;
- Ouellette, Andrew R;
- Neuner, Sarah;
- Dunn, Amy R;
- Hansen, Shania L;
- Wu, Yiyang;
- Dumitrescu, Logan;
- O'Connell, Kristen MS;
- Dammer, Eric B;
- Seyfried, Nicholas T.;
- Muzumdar, Sukalp;
- Gillis, Jesse;
- Robson, Paul;
- Zhang, Jigang;
- Hohman, Timothy J.;
- Philip, Vivek M.;
- Menon, Vilas
Publication type:
Article
Single amino acid change in the receptor binding domain of mouse APOE results in altered protein dynamics and worsened AD‐related cognitive impairment.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067225
By:
- Kaczorowski, Catherine C.;
- Singh, Surjeet;
- Kaur, Harpreet;
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Zhang, Jigang;
- Philip, Vivek M.;
- O'Connell, Kristen MS;
- Levine, Zachary;
- Dunn, Amy R
Publication type:
Article
Cell‐type Specific Effects of AD Mutations on Hippocampal Intrinsic Firing Properties in Genetically Diverse Mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.068784
By:
- Berchulski, Mariah R;
- Funke, Jonathan R;
- Hadad, Niran;
- O'Connell, Kristen MS;
- Kaczorowski, Catherine C.
Publication type:
Article
Identification of transcriptional signatures of cognitive resilience using single nucleus RNA sequencing.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.065947
By:
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Zhang, Jigang;
- Samuels, Michael;
- Robson, Paul;
- Philip, Vivek M.;
- Kaczorowski, Catherine C.
Publication type:
Article
Understanding comorbid metabolic dysfunctions in Alzheimer's disease using the AD‐BXDs.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.064808
By:
- Dai, Miko;
- Dunn, Amy R;
- Hadad, Niran;
- Cousineau, Cody;
- Bridges, Dave;
- Kaczorowski, Catherine C.;
- O'Connell, Kristen MS
Publication type:
Article
Brain‐wide spatial analysis reveals cell‐type‐specific genetic modifiers of Alzheimer's disease progression.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.061853
By:
- Gurdon, Brianna;
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Yates, Sharon;
- Puchades, Maja Amedjkouh;
- Bjaalie, Jan;
- Kaczorowski, Catherine C.
Publication type:
Article
APOE variant in the receptor binding domain confers cognitive resilience to familial Alzheimer's mutations and cell‐type specific gene expression changes in the hippocampus.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051794
By:
- King, Jillian L.;
- Anderson, David;
- Zhang, Jigang;
- Telpoukhovskaia, Maria;
- Hadad, Niran;
- Dunn, Amy R;
- Dumitrescu, Logan;
- Hohman, Timothy J.;
- O'Connell, Kristen MS;
- Philip, Vivek M.;
- Kaczorowski, Catherine C.
Publication type:
Article
Brain‐wide spatial analysis to identify region‐specific changes in cell composition associated with resilience to Alzheimer's disease in the AD‐BXD mouse population: Developing topics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047613
By:
- Gurdon, Brianna;
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Yates, Sharon;
- Puchades, Maja Amedjkouh;
- Bjaalie, Jan;
- Kaczorowski, Catherine C
Publication type:
Article
Mid‐life obesity and metabolic dysfunction in a genetically diverse mouse model of Alzheimer's disease: Genetics/genetic factors of Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044038
By:
- Dunn, Amy R.;
- Hadad, Niran;
- Kaczorowski, Catherine C.;
- O'Connell, Kristen M.S.
Publication type:
Article
Discovering genetic variants contributing to sleep dysfunction in presymptomatic Alzheimer's mice: Genetics/genetic factors of Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042937
By:
- Hadad, Niran;
- Dunn, Amy R.;
- O'Connell, Kristen M.S.;
- Kaczorowski, Catherine C.
Publication type:
Article
Single nuclear RNA sequencing reveals microglia diversity associated with cognitive resilience in the AD‐BXD mouse model of human Alzheimer's disease: Molecular and cell biology: Inflammatory and microglia‐mediated mechanisms in AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041543
By:
- Heuer, Sarah E.;
- Zhang, Jigang;
- Samuels, Michael;
- Hadad, Niran;
- Telpoukhovskaia, Maria;
- Ouellette, Andrew R.;
- O'Connell, Kristen M.S.;
- Menon, Vilas;
- Robson, Paul;
- Philip, Vivek;
- Kaczorowski, Catherine C.
Publication type:
Article
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.59616
By:
- Mann, Shivani N.;
- Hadad, Niran;
- Holte, Molly Nelson;
- Rothman, Alicia R.;
- Sathiaseelan, Roshini;
- Mondal, Samim Ali;
- Agbaga, Martin-Paul;
- Unnikrishnan, Archana;
- Subramaniam, Malayannan;
- Hawse, John;
- Huffman, Derek M.;
- Freeman, Willard M.;
- Stout, Michael B.
Publication type:
Article
Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies.
Published in:
GeroScience, 2019, v. 41, n. 5, p. 691, doi. 10.1007/s11357-019-00090-2
By:
- Chucair-Elliott, Ana J.;
- Ocanas, Sarah R.;
- Stanford, David R.;
- Hadad, Niran;
- Wronowski, Benjamin;
- Otalora, Laura;
- Stout, Michael B.;
- Freeman, Willard M.
Publication type:
Article
Role of DNA methylation in the dietary restriction mediated cellular memory.
Published in:
GeroScience, 2017, v. 39, n. 3, p. 331, doi. 10.1007/s11357-017-9976-8
By:
- Unnikrishnan, Archana;
- Jackson, Jordan;
- Matyi, Stephanie;
- Hadad, Niran;
- Wronowski, Benjamin;
- Georgescu, Constantin;
- Garrett, Karla;
- Wren, Jonathan;
- Freeman, Willard;
- Richardson, Arlan
Publication type:
Article
Analysis of DNA modifications in aging research.
Published in:
GeroScience, 2018, v. 40, n. 1, p. 11, doi. 10.1007/s11357-018-0005-3
By:
- Masser, Dustin R.;
- Hadad, Niran;
- Porter, Hunter;
- Stout, Michael B.;
- Unnikrishnan, Archana;
- Stanford, David R.;
- Freeman, Willard M.
Publication type:
Article
Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
Published in:
Epigenetics & Chromatin, 2016, v. 8, p. 1, doi. 10.1186/s13072-016-0080-6
By:
- Hadad, Niran;
- Masser, Dustin R.;
- Logan, Sreemathi;
- Wronowski, Benjamin;
- Mangold, Colleen A.;
- Clark, Nicholas;
- Otalora, Laura;
- Unnikrishnan, Archana;
- Ford, Matthew M.;
- Giles, Cory B.;
- Wren, Jonathan D.;
- Richardson, Arlan;
- Sonntag, William E.;
- Stanford, David R.;
- Freeman, Willard
Publication type:
Article
Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging.
Published in:
2017
By:
- Mangold, Colleen A.;
- Wronowski, Benjamin;
- Mei Du;
- Masser, Dustin R.;
- Hadad, Niran;
- Bixler, Georgina V.;
- Brucklacher, Robert M.;
- Ford, Matthew M.;
- Sonntag, William E.;
- Freeman, Willard M.;
- Du, Mei
Publication type:
journal article
Targeting cPLA<sub>2</sub> derived lipid hydroperoxides as a potential intervention for sarcopenia.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70792-7
By:
- Pharaoh, Gavin;
- Brown, Jacob L.;
- Sataranatarajan, Kavithalakshmi;
- Kneis, Parker;
- Bian, Jan;
- Ranjit, Rojina;
- Hadad, Niran;
- Georgescu, Constantin;
- Rabinovitch, Peter;
- Ran, Qitao;
- Wren, Jonathan D.;
- Freeman, Willard;
- Kinter, Michael;
- Richardson, Arlan;
- Van Remmen, Holly
Publication type:
Article
Early-life DNA methylation profiles are indicative of age-related transcriptome changes.
Published in:
Epigenetics & Chromatin, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13072-019-0306-5
By:
- Hadad, Niran;
- Masser, Dustin R.;
- Blanco-Berdugo, Laura;
- Stanford, David R.;
- Freeman, Willard M.
Publication type:
Article
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
Published in:
Age, 2016, v. 38, n. 3, p. 1, doi. 10.1007/s11357-016-9914-1
By:
- Masser, Dustin R.;
- Stanford, David R.;
- Hadad, Niran;
- Giles, Cory B.;
- Wren, Jonathan D.;
- Sonntag, William E.;
- Richardson, Arlan;
- Freeman, Willard M.
Publication type:
Article
Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex.
Published in:
Molecular Neurobiology, 2022, v. 59, n. 8, p. 4669, doi. 10.1007/s12035-022-02860-0
By:
- Ocañas, Sarah R.;
- Ansere, Victor A.;
- Tooley, Kyla B.;
- Hadad, Niran;
- Chucair-Elliott, Ana J.;
- Stanford, David R.;
- Rice, Shannon;
- Wronowski, Benjamin;
- Pham, Kevin D.;
- Hoffman, Jessica M.;
- Austad, Steven N.;
- Stout, Michael B.;
- Freeman, Willard M.
Publication type:
Article
Necroptosis increases with age and is reduced by dietary restriction.
Published in:
Aging Cell, 2018, v. 17, n. 4, p. 1, doi. 10.1111/acel.12770
By:
- Deepa, Sathyaseelan S.;
- Unnikrishnan, Archana;
- Matyi, Stephanie;
- Hadad, Niran;
- Richardson, Arlan
Publication type:
Article
Sexually divergent DNA methylation patterns with hippocampal aging.
Published in:
Aging Cell, 2017, v. 16, n. 6, p. 1342, doi. 10.1111/acel.12681
By:
- Masser, Dustin R.;
- Hadad, Niran;
- Porter, Hunter L.;
- Mangold, Colleen A.;
- Unnikrishnan, Archana;
- Ford, Matthew M.;
- Giles, Cory B.;
- Georgescu, Constantin;
- Dozmorov, Mikhail G.;
- Wren, Jonathan D.;
- Richardson, Arlan;
- Stanford, David R.;
- Freeman, Willard M.
Publication type:
Article

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