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- Title
Correlation of circulating dehydroepiandrosterone with activated protein C generation and carotid intima-media thickness in male patients with Type 2 diabetes.
- Authors
Suzuki, T.; Yano, Y.; Sakamoto, M.; Uemura, M.; Yasuma, T.; Onishi, Y.; Sasaki, R.; Matsumoto, K.; Hayashi, T.; Maruyama-Furuta, N.; Akatsuka, H.; Gabazza, E. C.; Sumida, Y.; Takei, Y.
- Abstract
Diabet. Med. 29, e41-e46 (2012) Abstract Aims Dehydroepiandrosterone exerts a protective effect against cardiovascular diseases. However, the relationship of dehydroepiandrosterone with the anticoagulant factor activated protein C, generated by the thrombin-thrombomodulin complex on vascular endothelial cells, remains unknown. This study aimed at studying the relationship between dehydroepiandrosterone and activated protein C generation in patients with Type 2 diabetes. Methods Sixty-two male patients with Type 2 diabetes were enrolled in this study. Data obtained from 40 healthy male subjects were used as controls. The plasma levels of dehydroepiandrosterone, the activated protein C-protein C inhibitor complex, high-sensitivity C-reactive protein and monocyte chemoattractant protein-1 were measured by enzyme immunoassays. Carotid intima-media thickness was measured by ultrasonography. Results The plasma levels of dehydroepiandrosterone (5.15 ± 2.81 vs. 3.76 ± 2.16 ng/ml; P < 0.005) and the activated protein C-protein C inhibitor complex (1.90 ± 1.07 vs. 1.02 ± 0.51 ng/ml; P < 0.001) were significantly lower in patients with diabetes than in normal subjects. Univariate analysis showed a significant correlation of the plasma level of dehydroepiandrosterone with that of the activated protein C-protein C inhibitor complex ( r = 0.48, P < 0.001), high-sensitivity C-reactive protein ( r = −0.30, P < 0.05) and with the mean intima-media thickness ( r = −0.28, P < 0.05) in patients with diabetes. Stepwise multiple regression analysis showed that the plasma level of dehydroepiandrosterone is significantly correlated with the plasma levels of the activated protein C-protein C inhibitor complex ( F = 18.06) and high-sensitivity C-reactive protein ( F = 4.94). There was no correlation between the plasma levels of dehydroepiandrosterone and monocyte chemoattractant protein-1. Conclusions These results suggest that lower circulating levels of dehydroepiandrosterone are associated with decreased activated protein C generation and higher intima-media thickness in patients with Type 2 diabetes.
- Subjects
JAPAN; ARTERIOSCLEROSIS risk factors; TYPE 2 diabetes complications; ANALYSIS of covariance; DEHYDROEPIANDROSTERONE; GLYCOSYLATED hemoglobin; INFLAMMATION; MULTIVARIATE analysis; PROTEINS; REGRESSION analysis; T-test (Statistics); ULTRASONIC imaging; EQUIPMENT &; supplies; CASE-control method; DATA analysis software; DESCRIPTIVE statistics
- Publication
Diabetic Medicine, 2012, Vol 29, Issue 7, pe41
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2012.03573.x