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- Title
CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model.
- Authors
Jong-Sun Yoo; Yun-Jung Lee; Joo Won Yoon; Kyeong Eun Hyung; Kwang Woo Hwang
- Abstract
Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal inducible expression. Our results indicate that transgenic expression of CTLA-4 in mouse T cells (CTLA-4-Tg T cells) results in reduced cell cycle progression and increased apoptosis of TCR-stimulated T cells. CTLA-4-Tg T cells display reduced T cell proliferation in an in vivo model of graft versus host disease (GVHD). These results further our understanding of how CTLA-4 can be manipulated to inhibit immune responses and may help development of new therapeutic strategies for clinical settings of autoimmunity and transplantation.
- Subjects
CELL membranes; T cells; TRANSGENIC animals; RODENTS; GRAFT versus host disease; AUTOIMMUNITY
- Publication
Korean Journal of Physiology & Pharmacology, 2012, Vol 16, Issue 5, p349
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2012.16.5.349