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- Title
Response to Dahl et al.: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes.
- Authors
Horowitz, Michael; Rayner, Christopher K.; Marathe, Chinmay S.; Wu, Tongzhi; Umapathysivam, Mahesh; Jones, Karen L.
- Abstract
We believe that the use of the paracetamol technique in isolation to evaluate the effects of GLP-1RAs on gastric emptying in humans should be abandoned and that scintigraphic measurement, using a standardized technique, should represent a mandatory regulatory requirement in the development of this drug class, including oral semaglutide. We have also pointed out that it is incorrect to suggest that a reduction in the AUC 0 to 1 hours, but not the AUC 0 to 5 hours, for paracetamol, indicates that an effect to slow gastric emptying is only sustained for 1 hour,2 simply because it may be anticipated that all the paracetamol will eventually be absorbed.
- Subjects
GASTRIC emptying; TYPE 2 diabetes; SEMAGLUTIDE; GLUCOSE metabolism; INSULIN aspart; GLYCEMIC index; GLUCAGON-like peptide 1
- Publication
Diabetes, Obesity & Metabolism, 2021, Vol 23, Issue 10, p2411
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.14473