We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized double-blind trial.
- Authors
Garg, S. K.; Ritchie, P. J.; Moser, E. G.; Snell-Bergeon, J. K.; Freson, B. J.; Hazenfield, R. M.
- Abstract
Colesevelam is indicated to lower low density lipoprotein cholesterol (LDL-C) in hyperlipidaemia and improve glycaemic control in adults with type 2 diabetes. This short-term pilot study evaluates its effects in type 1 diabetes. This double-blind, randomized, investigator-initiated, single-centred, 12-week pilot study evaluated 40 adults (age = 36.4 ± 9.4 years) with type 1 diabetes (duration = 20.4 ± 8.5 years) and hyperlipidaemia. It was powered to show a treatment difference of >10% LDL-C reduction. Subjects received 3.75 g/day colesevelam (n = 20) or placebo (n = 20) for 12 weeks. LDL-C and haemoglobin A1c (A1c) levels were assessed at screening (week 2), baseline (week 0) and every 4 weeks throughout the treatment duration. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) levels were measured during 4-h meal (Boost Plus, Nestle HealthCare Nutrition Inc., Florham Park, New Jersey, USA) challenge tests (MCT) at baseline and 12 weeks. Colesevelam treatment resulted in a significant reduction in LDL-C values at 4 weeks [−12.1% (95% CI: −20.1 to −4.1), p = 0.004] which was sustained for the study duration (p = 0.005 at 12 weeks). The treatment group also showed a significant change in A1c from baseline at week 4; however, this was not significant for the study duration. There was a significant median increase in GLP-1 levels during the first 2 h of the baseline MCT in the treated group but no difference at 12 weeks. During this short-term pilot study, colesevelam treatment effectively lowered LDL-C in patients with type 1 diabetes. Improvements in A1c seen at week 4 were not sustained. Effects on glycaemic control in subjects with type 1 diabetes may be related to a postprandial rise in GLP-1 levels and require further clinical study.
- Subjects
DIABETES; HYPERLIPIDEMIA; LOW density lipoproteins; CHOLESTEROL; TYPE 2 diabetes
- Publication
Diabetes, Obesity & Metabolism, 2011, Vol 13, Issue 2, p137
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2010.01320.x