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- Title
Perspective: New genetic tools for studying retinal development and disease.
- Authors
BRETT A. SCHWEERS; MICHAEL A. DYER
- Abstract
The use of knock-out and transgenic mice has been instrumental for advancing our understanding of retinal development and disease. In this perspective, we review existing genetic approaches to studying retinal development and present a series of new genetic tools that complement the use of standard knock-out and transgenic mice. Particular emphasis is placed on elucidating cell-autonomous and non-cell-autonomous roles of genes important for retinal development and disease in vivo. In addition, a series of gene-swapping vectors can be used to elucidate the function of proteins that regulate key processes in retinal development and a wide variety of retinopathies.
- Publication
Visual Neuroscience, 2005, Vol 22, Issue 5, p553
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/s0952523805225026