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- Title
Effect of dimeric netropsin analogue 15Lys-bis-Nt and acyclovir on the reproduction of herpes simplex virus type 1. The search for variants of herpes virus with drug resistance to 15Lys-bis-Nt and acyclovir.
- Authors
Andronova, V.; Grokhovsky, S.; Surovaya, A.; Gursky, G.; Galegov, G.
- Abstract
The article presents a study which examines the antiviral activity of dimeric netropsin derivative 15Lys-bis-Nt used in combination with herpes infection treatment drug acyclovir (ACV). The study used a multiciplity of infection (MOI) and demonstration of the international guidelines on ACV as treatment and prevention of recurrences of genital herpes. The study conclude the use of 15Lys-bis-Nt did not yield a drug-resistant with HSV-1 variant.
- Subjects
NETROPSIN; ANTIVIRAL agents; HERPES genitalis treatment; HERPES simplex prevention; ACYCLOVIR; THERAPEUTICS
- Publication
Doklady Biochemistry & Biophysics, 2015, Vol 460, Issue 1, p42
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672915010123