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- Title
Proteinuria—take a closer look!
- Authors
Bökenkamp, Arend
- Abstract
Proteinuria is a hallmark of kidney disease. Therefore, measurement of urine protein content plays a central role in any diagnostic work-up for kidney disease. In many cases, proteinuria analysis is restricted to the measurement of total protein content knowing that very high levels of proteinuria (nephrotic proteinuria) are characteristic of glomerular disease. Still, proteinuria can also be a manifestation of impaired tubular protein reabsorption or even be physiological. This review will discuss the physiology of renal protein handling and give guidance on a more sophisticated analysis of proteinuria differentiating albumin, low-molecular weight proteins and immunoglobulins. These non-invasive tests are available in most routine clinical laboratories and may guide the clinician in the diagnostic process before ordering far more expensive (molecular genetic testing) and/or invasive (kidney biopsy) diagnostics.
- Subjects
KIDNEY disease risk factors; PROTEIN metabolism; IMMUNOGLOBULINS; PROTEINS; PROTEINURIA; ALBUMINS; ROUTINE diagnostic tests; DISEASE complications
- Publication
Pediatric Nephrology, 2020, Vol 35, Issue 4, p533
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-019-04454-w