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- Title
Abnormalities of the APC/β-catenin pathway in endometrial cancer.
- Authors
Moreno-Bueno, Gema; Hardisson, David; Sanchez, Carolina; Sarrio, David; Cassia, Raul; Garcia-Rostan, Ginesa; Prat, Jaime; Mingzhou Guo; Herman, James G.; Matias-Guiu, Xavier; Esteller, Manel; Palacios, Jose
- Abstract
Presents a study that investigated the expression pattern of β- and γ-catenin in a group of several endometrial carcinomas (EC) including endometrioid endometrial carcinomas and non-endometrioid endometrial carcinomas. Presence of loss of heterozygosity and promoter hypermethylation of the adenomatous polyposis coli (APC) gene and mutations in the APC; Absence of APC mutations; Detection of APC promoter 1A hypermethylation in EC.
- Subjects
ENDOMETRIAL cancer; ENDOMETRIOSIS; ZYGOTES
- Publication
Oncogene, 2002, Vol 21, Issue 52, p7981
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205924