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- Title
Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ.
- Authors
Garcia-Fernandez, Luis F.; Losada, Alejandro; Alcaide, Victoria; Alvarez, Alberto M.; Cuadrado, Ana; Gonzalez, Laura; Nakayama, Keiko; Nakayama, Keiichi I.; Fernandez-Sousa, Jose Maria; Munoz, Alberto; Sanchez-Puelles, Jose Maria
- Abstract
Examines the molecular events induced by Aplidin™ in human HeLa tumor cells, characterizing the apoptotic program which causes its cytotoxicity. Analysis of the time-dependent effects of Aplidin™ on the viability of HeLa cells; Description of the oxidative stress on Aplidin™-mediated apoptosis; Effect of Aplidin™ on mitogen-activated protein kinases family activity.
- Subjects
HELA cells; APOPTOSIS; CELL-mediated cytotoxicity; PROTEIN kinases; MITOGENS
- Publication
Oncogene, 2002, Vol 21, Issue 49, p7533
- ISSN
0950-9232
- Publication type
Article