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- Title
Activation of NF-KB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
- Authors
Mitsiades, Constantine S.; Mitsiades, Nicholas; Poulaki, Vassiliki; Schlossman, Robert; Akiyama, Masaharu; Chauhan, Dharminder; Hideshima, Teru; Treon, Steven P.; Munshi, Nikhil C.; Richardson, Paul G.; Anderson, Kenneth C.
- Abstract
Presents a study that demonstrated the functions of insulin-like growth factor-1. Inducement of phosphorylation of the FKHRL-1 Forkhead transcription factor; Upregulation of a series of intracellular anti-apoptotic proteins; Effect on Apo2L/TRAIL-sensitivity of multiple myeloma cells.
- Subjects
SOMATOMEDIN; PHOSPHORYLATION; MYELOMA proteins
- Publication
Oncogene, 2002, Vol 21, Issue 37, p5673
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205664