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- Title
Safety of anti-varicella zoster virus vaccination in patients with multiple sclerosis treated with natalizumab: A case series.
- Authors
Lapucci, Caterina; Boccia, Vincenzo Daniele; Sirito, Tommaso; Cellerino, Maria; Mikulska, Malgorzata; Sticchi, Laura; Inglese, Matilde
- Abstract
The vaccination with live attenuated vaccines is generally not recommended during natalizumab (NTZ), as it is included among immunosuppressive/immunomodulating therapies. Nevertheless, considering the lack of evidence of a non-Central Nervous System (CNS) immunosuppressive effect of NTZ, after a risk/benefit evaluation, we decided to vaccinate four multiple sclerosis (MS) patients (three with an indication to switch to ocrelizumab for high-risk Progressive Multifocal Leukoencephalopathy (PML) and one for pregnancy planning). No vaccine-related adverse events of any type nor varicella zoster virus (VZV) infections were observed. To the best of our knowledge, these case series represent the first description of the good safety profile of anti-VZV vaccination in MS patients during NTZ treatment.
- Subjects
CHICKENPOX; MULTIPLE sclerosis; PROGRESSIVE multifocal leukoencephalopathy; NATALIZUMAB; VARICELLA-zoster virus diseases; VACCINATION; NERVOUS system
- Publication
Multiple Sclerosis Journal, 2023, Vol 29, Issue 11/12, p1514
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585231204121