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- Title
Multiple sclerosis: Is there a risk of worsening after yellow fever vaccination?
- Authors
Papeix, Caroline; Mazoyer, Julie; Maillart, Elisabeth; Bensa, Caroline; Dubessy, Anne-Laure; Goujon, Catherine; Launay, Odile; Lebrun-Frénay, Christine; Louapre, Céline; Mrejen, Serge; Pourcher, Valérie; Rosenheim, Michel; Stankoff, Bruno; Vidal, Jean-Sebastien; Lubetzki, Catherine
- Abstract
Background: Yellow fever vaccine (YFV) is not advised for multiple sclerosis (MS) patients because of the potential risk of post-vaccine relapses. Objective: To assess the risk of relapsing-remitting multiple sclerosis (RR-MS) worsening after YFV. Methods: Non-interventional observational retrospective, exposed/non-exposed cohort study nested in the French national cohort including MS. Results: 128 RR-MS were included. The 1-year annualized relapse rate (ARR) following YFV did not differ between exposed: 0.219 (0.420) and non-exposed subjects: 0.208 (0.521) (p = 0.92). Time to first relapse was not different between groups (adjusted hazard ratio (HR) = 1.33; 95% confidence interval (CI) = 0.53–3.30, p = 0.54). Conclusion: These results suggest that YFV does not worsen the course of RR-MS.
- Subjects
YELLOW fever; MULTIPLE sclerosis; VACCINATION; CONFIDENCE intervals; DISEASE relapse
- Publication
Multiple Sclerosis Journal, 2021, Vol 27, Issue 14, p2280
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211006372