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The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.
Published in:
PLoS Biology, 2016, v. 14, n. 5, p. 1, doi. 10.1371/journal.pbio.1002467
By:
- Laitman, Benjamin M.;
- Asp, Linnéa;
- Mariani, John N.;
- Zhang, Jingya;
- Liu, Jia;
- Sawai, Setsu;
- Chapouly, Candice;
- Horng, Sam;
- Kramer, Elisabeth G.;
- Mitiku, Nesanet;
- Loo, Hannah;
- Burlant, Natalie;
- Pedre, Xiomara;
- Hara, Yuko;
- Nudelman, German;
- Zaslavsky, Elena;
- Lee, Young-Min;
- Braun, David A.;
- Lu, Q. Richard;
- Narla, Goutham
Publication type:
Article
Krüppel-like factor 6 regulates mitochondrial function in the kidney.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 3, p. 1347, doi. 10.1172/JCI77084
By:
- Mallipattu, Sandeep K.;
- Horne, Sylvia J.;
- D'Agati, Vivette;
- Narla, Goutham;
- Ruijie Liu;
- Frohman, Michael A.;
- Dickman, Kathleen;
- Chen, Edward Y.;
- Ma'ayan, Avi;
- Bialkowska, Agnieszka B.;
- Ghaleb, Amr M.;
- Nandan, Mandayam O.;
- Jain, Mukesh K.;
- Daehn, Ilse;
- Chuang, Peter Y.;
- Yang, Vincent W.;
- He, John C.
Publication type:
Article
Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 7, p. 2637, doi. 10.1172/JCI62058
By:
- Sangodkar, Jaya;
- Dhawan, Neil S.;
- Melville, Heather;
- Singh, Varan J.;
- Yuan, Eric;
- Rana, Huma;
- Izadmehr, Sudeh;
- Farrington, Caroline;
- Mazhar, Sahar;
- Katz, Suzanna;
- Albano, Tara;
- Arnovitz, Pearlann;
- Okrent, Rachel;
- Ohlmeyer, Michael;
- Galsky, Matthew;
- Burstein, David;
- Zhang, David;
- Politi, Katerina;
- DiFeo, Analisa;
- Narla, Goutham
Publication type:
Article
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
Published in:
2008
By:
- Narla, Goutham;
- DiFeo, Analisa;
- Fernandez, Yolanda;
- Dhanasekaran, Saravana;
- Fei Huang;
- Sangodkar, Jaya;
- Hod, Eldad;
- Leake, Devin;
- Friedman, Scott L.;
- Hall, Simon J.;
- Chinnaiyan, Arul M.;
- Gerald, William L.;
- Rubin, Mark A.;
- Martignetti, John A.;
- Huang, Fei
Publication type:
journal article
Structural Genetics to Understand Holoenzyme Assembly and Substrate Selection of Diverse Multimeric Serine-threonine Phosphatases.
Published in:
Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.354
By:
- Huang, Wei;
- Veis, Jiri;
- Day, Alexander;
- Cui, Shouqing;
- Leonard, Daniel;
- Narla, Goutham;
- Ogris, Egon;
- Taylor, Derek J
Publication type:
Article
Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma.
Published in:
Clinical Chemistry & Laboratory Medicine, 2010, v. 48, n. 8, p. 1167, doi. 10.1515/CCLM.2010.219
By:
- Tchirkov, Andrei;
- Sapin, Vincent;
- Marceau, Geoffroy;
- Chautard, Emmanuel;
- Narla, Goutham;
- Veronese, Lauren;
- Friedman, Scott;
- Khalil, Toufic;
- Vago, Philippe;
- Kemeny, Jean-Louis;
- Verrelle, Pierre
Publication type:
Article
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.
Published in:
Oncogene, 2004, v. 23, n. 29, p. 5077, doi. 10.1038/sj.onc.1207662
By:
- Kimmelman, Alec C.;
- Qiao, Rui F.;
- Narla, Goutham;
- Banno, Asoka;
- Lau, Nelson;
- Bos, Paula D.;
- Rodriguez, Nelson Nuñez;
- Liang, Bertrand C.;
- Guha, Abhijit;
- Martignetti, John A.;
- Friedman, Scott L.;
- Chan, Andrew M.
Publication type:
Article
Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer.
Published in:
Cancer Medicine, 2023, v. 12, n. 7, p. 8378, doi. 10.1002/cam4.5558
By:
- Shatat, Mohammad A.;
- Gauthier, Betsy;
- Yoon, Suzy;
- Yuan, Eric;
- Yang, Peiying;
- Narla, Goutham;
- Dowlati, Afshin;
- Lee, Richard T.
Publication type:
Article
The impact of phosphatases on proliferative and survival signaling in cancer.
Published in:
Cellular & Molecular Life Sciences, 2018, v. 75, n. 15, p. 2695, doi. 10.1007/s00018-018-2826-8
By:
- Narla, Goutham;
- Sangodkar, Jaya;
- Ryder, Christopher B.
Publication type:
Article
Targeting Translational Control in Cancer Using Small Molecule Activators of PP2A.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L7668
By:
- Jonas, Kayla A.;
- Lum, Michelle A.;
- Black, Adrian R.;
- Narla, Goutham;
- Jennifer, Black D.
Publication type:
Article
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.
Published in:
FEBS Journal, 2016, v. 283, n. 6, p. 1004, doi. 10.1111/febs.13573
By:
- Sangodkar, Jaya;
- Farrington, Caroline C.;
- McClinch, Kimberly;
- Galsky, Matthew D.;
- Kastrinsky, David B.;
- Narla, Goutham
Publication type:
Article
Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity.
Published in:
2020
By:
- Risom, Tyler;
- Xiaoyan Wang;
- Juan Liang;
- Xiaoli Zhang;
- Pelz, Carl;
- Campbell, Lydia G.;
- Eng, Jenny;
- Koei Chin;
- Farrington, Caroline;
- Narla, Goutham;
- Langer, Ellen M.;
- Xiao-Xin Sun;
- Yulong Su;
- Daniel, Colin J.;
- Mu-Shui Dai;
- Löhr, Christiane V.;
- Sears, Rosalie C.;
- Wang, Xiaoyan;
- Liang, Juan;
- Zhang, Xiaoli
Publication type:
journal article
Deregulating MYC in a model of HER2<sup>+</sup> breast cancer mimics human intertumoral heterogeneity.
Published in:
Journal of Clinical Investigation, 2020, v. 130, n. 1, p. 231, doi. 10.1172/JCI126390
By:
- Risom, Tyler;
- Xiaoyan Wang;
- Juan Liang;
- Xiaoli Zhang;
- Pelz, Carl;
- Campbell, Lydia G.;
- Eng, Jenny;
- Koei Chin;
- Farrington, Caroline;
- Narla, Goutham;
- Langer, Ellen M.;
- Xiao-Xin Sun;
- Yulong Su;
- Daniel, Colin J.;
- Mu-Shui Dai;
- Löhr, Christiane V.;
- Sears, Rosalie C.
Publication type:
Article
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
Published in:
PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3000803
By:
- He, Xuxiao;
- Li, Min;
- Yu, Hongming;
- Liu, Guijun;
- Wang, Ningning;
- Yin, Chunzhao;
- Tu, Qiaochu;
- Narla, Goutham;
- Tao, Yongzhen;
- Cheng, Shuqun;
- Yin, Huiyong
Publication type:
Article
Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator.
Published in:
Proteomics, 2017, v. 17, n. 22, p. n/a, doi. 10.1002/pmic.201700214
By:
- Wiredja, Danica D.;
- Ayati, Marzieh;
- Mazhar, Sahar;
- Sangodkar, Jaya;
- Maxwell, Sean;
- Schlatzer, Daniela;
- Narla, Goutham;
- Koyutürk, Mehmet;
- Chance, Mark R.
Publication type:
Article
Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.
Published in:
Carcinogenesis, 2006, v. 27, n. 2, p. 216
By:
- Alexander Kirschenbaum;
- Xin-Hua Liu;
- Shen Yao;
- Goutham Narla;
- Scott L. Friedman;
- John A. Martignetti;
- Alice C. Levine
Publication type:
Article
KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.
Published in:
International Journal of Cancer, 2007, v. 121, n. 9, p. 1976, doi. 10.1002/ijc.22926
By:
- Teixeira, Miriam S.;
- Camacho-Vanegas, Olga;
- Fernandez, Yolanda;
- Narla, Goutham;
- DiFeo, Analisa;
- Lee, Bryant;
- Kalir, Tamara;
- Friedman, Scott L.;
- Schlecht, Nicolas F.;
- Genden, Eric M.;
- Urken, Mark;
- Brandwein-Gensler, Margaret;
- Martignetti, John A.
Publication type:
Article
Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.
Published in:
International Journal of Cancer, 2007, v. 121, n. 6, p. 1390, doi. 10.1002/ijc.22809
By:
- Camacho-Vanegas, Olga;
- Narla, Goutham;
- Teixeira, Miriam S.;
- DiFeo, Analisa;
- Misra, Anjan;
- Singh, Gobind;
- Chan, Andrew M.;
- Friedman, Scott L.;
- Feuerstein, Burt G.;
- Martignetti, John A.
Publication type:
Article
IKKα negatively regulates ASC-dependent inflammasome activation.
Published in:
Nature Communications, 2014, v. 5, n. 9, p. 4977, doi. 10.1038/ncomms5977
By:
- Martin, Bradley N.;
- Wang, Chenhui;
- Willette-Brown, Jami;
- Herjan, Tomasz;
- Gulen, Muhammet F.;
- Zhou, Hao;
- Bulek, Katarzyna;
- Franchi, Luigi;
- Sato, Takashi;
- Alnemri, Emad S.;
- Narla, Goutham;
- Zhong, Xiao-Ping;
- Thomas, James;
- Klinman, Dennis;
- Fitzgerald, Katherine A.;
- Karin, Michael;
- Nuñez, Gabriel;
- Dubyak, George;
- Hu, Yinling;
- Li, Xiaoxia
Publication type:
Article
microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.
Published in:
Nature Communications, 2014, v. 5, n. 1, p. 2977, doi. 10.1038/ncomms3977
By:
- Parikh, Aditya;
- Lee, Christine;
- Joseph, Peronne;
- Marchini, Sergio;
- Baccarini, Alessia;
- Kolev, Valentin;
- Romualdi, Chiara;
- Fruscio, Robert;
- Shah, Hardik;
- Wang, Feng;
- Mullokandov, Gavriel;
- Fishman, David;
- D'Incalci, Maurizio;
- Rahaman, Jamal;
- Kalir, Tamara;
- Redline, Raymond W.;
- Brown, Brian D.;
- Narla, Goutham;
- DiFeo, Analisa
Publication type:
Article
Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia".
Published in:
Science Translational Medicine, 2019, v. 11, n. 501, p. 1, doi. 10.1126/scitranslmed.aau0416
By:
- Perrotti, Danilo;
- Agarwal, Anupriya;
- Lucas, Claire M.;
- Narla, Goutham;
- Neviani, Paolo;
- Odero, Maria D.;
- Ruvolo, Peter P.;
- Verrills, Nicole M.
Publication type:
Article
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
Published in:
Science Translational Medicine, 2018, v. 10, n. 450, p. 1, doi. 10.1126/scitranslmed.aaq1093
By:
- Kauko, Otto;
- O'Connor, Caitlin M.;
- Kulesskiy, Evgeny;
- Sangodkar, Jaya;
- Aakula, Anna;
- Izadmehr, Sudeh;
- Yetukuri, Laxman;
- Yadav, Bhagwan;
- Padzik, Artur;
- Laajala, Teemu Daniel;
- Haapaniemi, Pekka;
- Momeny, Majid;
- Varila, Taru;
- Ohlmeyer, Michael;
- Aittokallio, Tero;
- Wennerberg, Krister;
- Narla, Goutham;
- Westermarck, Jukka
Publication type:
Article
Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression.
Published in:
2011
By:
- Radbill, Brian;
- Gupta, Ritu;
- Ramirez, Maria;
- DiFeo, Analisa;
- Martignetti, John;
- Alvarez, Carlos;
- Friedman, Scott;
- Narla, Goutham;
- Vrabie, Raluca;
- Bowles, Robert;
- Saiman, Yedidya;
- Bansal, Meena;
- Radbill, Brian D;
- Ramirez, Maria Celeste M;
- Martignetti, John A;
- Alvarez, Carlos E;
- Friedman, Scott L;
- Bansal, Meena B
Publication type:
journal article
Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89866-1
By:
- Kaemmer, Courtney A.;
- Umesalma, Shaikamjad;
- Maharjan, Chandra K.;
- Moose, Devon L.;
- Narla, Goutham;
- Mott, Sarah L.;
- Zamba, Gideon K. D.;
- Breheny, Patrick;
- Darbro, Benjamin W.;
- Bellizzi, Andrew M.;
- Henry, Michael D.;
- Quelle, Dawn E.
Publication type:
Article
Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells.
Published in:
International Journal of Cancer, 2009, v. 125, n. 4, p. 774, doi. 10.1002/ijc.24325
By:
- Xiong, Su Dao;
- Yu, Kang;
- Liu, Xin Hua;
- Yin, Li Hui;
- Kirschenbaum, Alexander;
- Yao, Shen;
- Narla, Goutham;
- DiFeo, Analisa;
- Wu, Jian Buo;
- Yuan, Yong;
- Ho, Shuk-Mei;
- Lam, Ying Wai;
- Levine, Alice C.
Publication type:
Article
KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival.
Published in:
Science Translational Medicine, 2013, v. 5, n. 169, p. 1, doi. 10.1126/scitranslmed.3004688
By:
- Hatami, Raheleh;
- Sieuwerts, Anieta M.;
- Izadmehr, Sudeh;
- Zhong Yao;
- Rui Fang Qiao;
- Papa, Luena;
- Look, Maxime P.;
- Smid, Marcel;
- Ohlssen, Jessica;
- Levine, Alice C.;
- Germain, Doris;
- Burstein, David;
- Kirschenbaum, Alexander;
- DiFeo, Analisa;
- Foekens, John A.;
- Narla, Goutham
Publication type:
Article
Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series.
Published in:
Case Reports in Oncology, 2021, v. 14, n. 1, p. 224, doi. 10.1159/000511566
By:
- Lee, Richard T.;
- Yang, Peiying;
- Alahmadi, Asrar;
- McQuade, Jennifer;
- Yuan, Eric;
- Difeo, Analisa;
- Narla, Goutham;
- Kaseb, Ahmed
Publication type:
Article
Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene
Published in:
FEBS Letters, 2010, v. 584, n. 5, p. 1006, doi. 10.1016/j.febslet.2010.01.049
By:
- Lee, Ursula E.;
- Ghiassi-Nejad, Zahra;
- Paris, Andrew J.;
- Yea, Steven;
- Narla, Goutham;
- Walsh, Martin;
- Friedman, Scott L.
Publication type:
Article
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Published in:
Clinical Science, 2021, v. 135, n. 17, p. 2085, doi. 10.1042/CS20210315
By:
- Xianming Zhou;
- Chao Zhang;
- Fei Xie;
- Wei Wei;
- Rui Li;
- Qian Xu;
- Yu Wang;
- Klenotic, Philip A.;
- Narla, Goutham;
- Nianguo Dong;
- Zhiyong Lin
Publication type:
Article
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.
Published in:
Clinical Science, 2021, v. 135, n. 13, p. 1445, doi. 10.1042/CS20201367
By:
- Brautigan, David L.;
- Farrington, Caroline;
- Narla, Goutham
Publication type:
Article
KLF6 degradation after apoptotic DNA damage
Published in:
FEBS Letters, 2006, v. 580, n. 30, p. 6981, doi. 10.1016/j.febslet.2006.10.077
By:
- Banck, Michaela S.;
- Beaven, Simon W.;
- Narla, Goutham;
- Walsh, Martin J.;
- Friedman, Scott L.;
- Beutler, Andreas S.
Publication type:
Article
10:30: KLF6 LOH Is Linked to Recurrence and Lower Survival in HNSSC
Published in:
2007
By:
- Teixeira, Miriam S.;
- Camacho-Vanegas, Olga;
- Fernandez, Yolanda;
- Narla, Goutham;
- Difeo, Analisa;
- Schlecht, Nicolas F.;
- Brandwein-Gensler, Margaret;
- Martignetti, John A.
Publication type:
Abstract

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