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- Title
The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria.
- Authors
Thorsen, Jonathan; Li, Xuan Ji; Peng, Shuang; Sunde, Rikke Bjersand; Shah, Shiraz A.; Bhattacharyya, Madhumita; Poulsen, Casper Sahl; Poulsen, Christina Egeø; Leal Rodriguez, Cristina; Widdowson, Michael; Neumann, Avidan Uriel; Trivedi, Urvish; Chawes, Bo; Bønnelykke, Klaus; Bisgaard, Hans; Sørensen, Søren J.; Stokholm, Jakob
- Abstract
Culture techniques have associated colonization with pathogenic bacteria in the airways of neonates with later risk of childhood asthma, whereas more recent studies utilizing sequencing techniques have shown the same phenomenon with specific anaerobic taxa. Here, we analyze nasopharyngeal swabs from 1 month neonates in the COPSAC2000 prospective birth cohort by 16S rRNA gene sequencing of the V3-V4 region in relation to asthma risk throughout childhood. Results are compared with previous culture results from hypopharyngeal aspirates from the same cohort and with hypopharyngeal sequencing data from the later COPSAC2010 cohort. Nasopharyngeal relative abundance values of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis are associated with the same species in the hypopharyngeal cultures. A combined pathogen score of these bacteria's abundance values is associated with persistent wheeze/asthma by age 7. No other taxa are associated. Compared to the hypopharyngeal aspirates from the COPSAC2010 cohort, the anaerobes Veillonella and Prevotella, which have previously been implicated in asthma development, are less commonly detected in the COPSAC2000 nasopharyngeal samples, but correlate with the pathogen score, hinting at latent community structures that bridge current and previous results. These findings have implications for future asthma prevention efforts. Here, Thorsen et al. bridge new and previous results from the COPSAC2000 prospective birth cohort and the later COPSAC2010 cohort, by constructing a combined bacterial pathogen score with implications for the early-life airway microbiota and the risk of asthma later in childhood
- Subjects
ASTHMA in children; NEWBORN infants; MORAXELLA catarrhalis; HAEMOPHILUS influenzae; STREPTOCOCCUS pneumoniae; ANAEROBIC microorganisms; PATHOGENIC bacteria
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-42309-z