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- Title
Hemp seeds attenuate loperamide-induced constipation in mice.
- Authors
Huang Hua; Wang Yongtong; Ding Xufengm; Li Fang; Gu Jing; Zeng Fumao; Jiang Jie; Ji Lijiang
- Abstract
Constipation is a common gastrointestinal disease that seriously a ects human physical and mental health. Studies have reported that hemp seeds can improve constipation, however the specific mechanism is still unclear. This study investigates that hemp seed (HS) and its water-ethanol extract (HSE) attenuates loperamide-induced constipation in mice. The research results show that: the fecal water content and small intestinal transit rate of mice in the hemp seed group and hemp seed hydroalcoholic extract groupwere significantly increased compared with MC group, and the first red feces defecation time was significantly shortened; HS and HSE significantly influence serum levels of Gastrin (Gas), motilin (MTL), substance P (SP), and endothelin (ET), potentially mediating their e ects on gastrointestinal motility. HS and HSE can improve colon inflammation in constipated mice with H&E staining. Compared with the model of constipation group, the content of short-chain fatty acids in the HS group and HSE group increased significantly. Gut microbiome studies have shown that the structure and abundance of intestinal flora are altered. HS and HSE changed the abundance of Odoribacter, Bacteroide, Lactobacillus and Prevotella. Together, these results suggest that HS have the potential to stimulate the proliferation of beneficial gut microbes and promote intestinal motility, thereby improving gut health and relieving symptoms of constipation.
- Subjects
ENDOTHELINS; DEFECATION; CONSTIPATION; SHORT-chain fatty acids; HEMP; SUBSTANCE P; GASTROINTESTINAL motility
- Publication
Frontiers in Microbiology, 2024, p01
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2024.1353015