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- Title
The modification of HLA-B27-positive lymphocytes by the culture filtrate of Klebsiella K43 BTS 1 is a metabolically active process.
- Authors
Sullivan, J. S.; Geczy, A. F.
- Abstract
The culture filtrate of some bacteria contains a modifying factor which specifically interacts with the cells of HLA-B27-positive normal individuals (BS+AS-); this modification results in a serologically detectable change similar to that seen on the cells of patients with ankylosing spondylitis (B27+ AS+) . Puromycin. 5-azacytidine, actinomycin D. cyclosporin A, dexamethasone, indomethacin, colchicine, quinacrine, chlorpromazine but not tunicamycincan effectively inhibit the in vitro modification of HLA-B27-positive lymphocytes from normal individuals. These studies suggest that a number of different metabolic pathways may be involved in the modification of B27+ AS- lymphocytes by certain enteric antigens.
- Subjects
BACTERIA; PROKARYOTES; CHLORPROMAZINE; PHENOTHIAZINE; SEROTONIN antagonists; ACTINOMYCIN C
- Publication
Clinical & Experimental Immunology, 1985, Vol 62, Issue 3, p672
- ISSN
0009-9104
- Publication type
Article