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- Title
MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer.
- Authors
Gopinath, Subash C. B.; Perumal, Veeradasan; Xuan, Shijin
- Abstract
This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer.
- Subjects
BREAST cancer; ELECTRODES; CANCER invasiveness; DETECTION limit
- Publication
3 Biotech, 2020, Vol 10, Issue 6, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-020-02261-x