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- Title
An experimental spinal cord injury rat model using customized impact device: A cost-effective approach.
- Authors
Vijayaprakash, K. M.; Sridharan, N.
- Abstract
Till date, NYU MASCIS (New York University, Multicenter Animal Spinal Cord Injury Study) impactor and Ohio State University electromagnetic spinal cord injury device impactor were under use for simulating an experimental spinal cord injury in rodents; functional recovery being assessed through Basso, Beattie and Bresnahan (BBB) scoring method which is an open field behavior based scoring system. Although, the cited impactors are state-of-art devices, affordability to scientists in developing and under developed countries is questionable. Since the acquisition of these impact devices are expensive, we designed a customized impact device based on the requirement, satisfying all the parameters to withstand a standard animal model for contusion type of spinal cord injury at the thoracic level without compromising the lesion reproducibility. Here, a spinal cord contusion is created using a blunt-force impactor in male Wistar rats. Our method gave consistent lesion effects as evaluated by behavior scoring methods. All the animals showed equal degree of performance in tests like narrow beam, inclined plane and horizontal ladder and in BBB scores (open field locomotor test). The aim of presenting our experience is to reinstate the fact that lack of affordability to get sophisticated instrumentation need not be a hurdle in the pursuit of science.
- Subjects
SPINAL cord injuries; THERAPEUTICS; ELECTROMAGNETIC compatibility; LABORATORY rats; BLUNT trauma; DEVELOPING countries
- Publication
Journal of Pharmacology & Pharmacotherapeutics, 2013, Vol 4, Issue 3, p211
- ISSN
0976-500X
- Publication type
Article
- DOI
10.4103/0976-500X.114607