We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Wearable Insulin Biosensors for Diabetes Management: Advances and Challenges.
- Authors
Psoma, Sotiria D.; Kanthou, Chryso
- Abstract
We present a critical review of the current progress in wearable insulin biosensors. For over 40 years, glucose biosensors have been used for diabetes management. Measurement of blood glucose is an indirect method for calculating the insulin administration dosage, which is critical for insulin-dependent diabetic patients. Research and development efforts aiming towards continuous-insulin-monitoring biosensors in combination with existing glucose biosensors are expected to offer a more accurate estimation of insulin sensitivity, regulate insulin dosage and facilitate progress towards development of a reliable artificial pancreas, as an ultimate goal in diabetes management and personalised medicine. Conventional laboratory analytical techniques for insulin detection are expensive and time-consuming and lack a real-time monitoring capability. On the other hand, biosensors offer point-of-care testing, continuous monitoring, miniaturisation, high specificity and sensitivity, rapid response time, ease of use and low costs. Current research, future developments and challenges in insulin biosensor technology are reviewed and assessed. Different insulin biosensor categories such as aptamer-based, molecularly imprinted polymer (MIP)-based, label-free and other types are presented among the latest developments in the field. This multidisciplinary field requires engagement between scientists, engineers, clinicians and industry for addressing the challenges for a commercial, reliable, real-time-monitoring wearable insulin biosensor.
- Subjects
RESEARCH &; development; INSULIN; BIOSENSORS; APTAMERS; ARTIFICIAL pancreases; BLOOD sugar measurement; IMPRINTED polymers; INSULIN therapy; INDIVIDUALIZED medicine
- Publication
Biosensors (2079-6374), 2023, Vol 13, Issue 7, p719
- ISSN
2079-6374
- Publication type
Article
- DOI
10.3390/bios13070719