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- Title
A Polyherbal Mixture with Nutraceutical Properties for Ruminants: A Meta-Analysis and Review of BioCholine Powder.
- Authors
Mendoza-Martínez, Germán David; Orzuna-Orzuna, José Felipe; Roque-Jiménez, José Alejandro; Gloria-Trujillo, Adrián; Martínez-García, José Antonio; Sánchez-López, Nallely; Hernández-García, Pedro Abel; Lee-Rangel, Héctor Aaron
- Abstract
Simple Summary: BioCholine Powder can improve domestic ruminants' (sheep, goats, calves, and cows) productive performance. The objective of this study was to review published data and evaluate the effects of dietary polyherbal supplementation in lambs, ewes, dairy goats, and cows on productive performance and blood serum metabolites through a meta-analysis and by a comparison of the estimated net energy for maintenance (NEm) and gain (NEg) in lambs, which was expressed as a percentage of change in the polyherbal mixture regarding their control using a Chi-squared test. BioCholine supplementation improved small ruminants' daily gain and milk production and modified some blood metabolites. The results confirm that including BioCholine Powder in ruminant diets shows nutraceutical effects that outweigh those of phosphatidylcholine bypass and that benefits in growth, milk production, and health can therefore be expected with its dietary inclusion. BioCholine Powder is a polyherbal feed additive composed of Achyrantes aspera, Trachyspermum ammi, Azadirachta indica, and Citrullus colocynthis. The objective of this study was to analyze published results that support the hypothesis that the polyherbal product BioCholine Powder has rumen bypass choline metabolites through a meta-analysis and effect size analysis (ES). Using Scopus, Web of Science, ScienceDirect, PubMed, and university dissertation databases, a systematic search was conducted for experiments published in scientific documents that evaluated the effects of BioCholine supplementation on the variables of interest. The analyzed data were extracted from twenty-one publications (fifteen scientific articles, three abstracts, and three graduate dissertations available in institutional libraries). The studies included lamb growing–finishing, lactating ewes and goats, calves, and dairy cows. The effects of BioCholine were analyzed using random effects statistical models to compare the weighted mean difference (WMD) between BioCholine-supplemented ruminants and controls (no BioCholine). Heterogeneity was explored, and three subgroup analyses were performed for doses [(4 (or 5 g/d), 8 (10 g/d)], supplementation in gestating and lactating ewes (pre- and postpartum supplementation), and blood metabolites by species and physiological state (lactating goats, calves, lambs, ewes). Supplementation with BioCholine in sheep increased the average daily lamb gain (p < 0.05), final body weight (p < 0.01), and daily milk yield (p < 0.05) without effects on intake or feed conversion. Milk yield was improved in small ruminants with BioCholine prepartum supplementation (p < 0.10). BioCholine supplementation decreased blood urea (p < 0.01) and increased levels of the liver enzymes alanine transaminase (ALT; p < 0.10) and albumin (p < 0.001). BioCholine doses over 8 g/d increased blood glucose, albumin (p < 0.10), cholesterol, total protein, and globulin (p < 0.05). The ES values of BioCholine in retained energy over the control in growing lambs were +7.15% NEm (p < 0.10) and +9.25% NEg (p < 0.10). In conclusion, adding BioCholine Powder to domestic ruminants' diets improves productive performance, blood metabolite indicators of protein metabolism, and liver health, showing its nutraceutical properties where phosphatidylcholine prevails as an alternative that can meet the choline requirements in ruminants.
- Subjects
RUMINANTS; SHEEP milk; GOATS; MILK proteins; RANDOM effects model; POWDERS; WATERMELONS
- Publication
Animals (2076-2615), 2024, Vol 14, Issue 5, p667
- ISSN
2076-2615
- Publication type
Article
- DOI
10.3390/ani14050667