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- Title
Cardiac-Autonomic Imbalance and Baroreflex Dysfunction in the Renovascular Angiotensin-Dependent Hypertensive Mouse.
- Authors
Campagnaro, Bianca P.; Gava, Agata L.; Meyrelles, Silvana S.; Vasquez, Elisardo C.
- Abstract
Mouse models provide powerful tools for studying the mechanisms underlying the dysfunction of the autonomic reflex control of cardiovascular function and those involved in cardiovascular diseases. The established murine model of two-kidney, one clip (2K1C) angiotensin II-dependent hypertension represents a useful tool for studying the neural control of cardiovascular function. In this paper, we discuss themain contributions from our laboratory and others regarding cardiac-autonomic imbalance and baroreflex dysfunction. We show recent data from the angiotensin-dependent hypertensive mouse demonstrating DNA damage and oxidative stress using the comet assay and flow cytometry, respectively. Finally, we highlight the relationships between angiotensin and peripheral and central nervous system areas of cardiovascular control and oxidative stress in the 2K1C hypertensive mouse.
- Subjects
HEART physiology; KIDNEY physiology; SYMPATHETIC nervous system physiology; ANIMAL experimentation; BAROREFLEXES; BIOLOGICAL models; BODY weight; DNA; HEART beat; HYPERTENSION; MICE; RENIN-angiotensin system
- Publication
International Journal of Hypertension, 2012, p1
- ISSN
2090-0384
- Publication type
Article
- DOI
10.1155/2012/968123