An editorial is presented on latest research findings and evidence related to Celiac Disease (CD) and a Gluten-Free Diet (GFD). Topics include Celiac disease (CD) being a systemic disease causing chronic enteropathy of the small intestine and developing through an inadequate immune response to gluten in genetically predisposed individuals; and affecting any organ or tissue with gastrointestinal, extraintestinal, seronegative, or nonresponsive manifestations.