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- Title
Underweight and Weight Change Increases End-Stage Renal Disease Risk in Patients with Diabetes: A Nationwide Population-Based Cohort Study.
- Authors
Bae, Eun Hui; Oh, Tae Ryom; Suh, Sang Heon; Yang, Eun Mi; Choi, Hong Sang; Kim, Chang Seong; Ma, Seong Kwon; Kim, Bongseong; Han, Kyung-Do; Kim, Soo Wan
- Abstract
Weight variability has known as a risk factor for cardiovascular events and mortality. However, its effect on end-stage renal disease (ESRD) development remains controversial. We investigated the relationship between weight change and ESRD risk. Overall, 97,029 patients with DM aged >20 years were selected from the Korean National Health Screening Program 2009–2012. Weight change was defined as differences in body weight from the index year to 2 years later. Newly diagnosed ESRD was observed until 2017 end. Over a 5.1-year median follow-up period, ESRD was newly diagnosed in 7932 (4.81%) DM patients. BMI < 18.5 kg/m2 and waist circumferences <85/80 and >100/95 cm were ESRD risk factors. ESRD risk increased with increasing weight change; ≥10% weight loss (hazard ratio [HR], 1.247) followed by ≥10% weight gain (1.247) was associated with a higher HR than ≤5% weight change after adjusting for several confounding factors. The association between weight change and ESRD risk in a subgroup analysis was significantly stronger in patients aged <65 years, without proteinuria, with BMI ≥ 25, with DM duration <5 years, and prescribed less than 3 classes of DM medication. Underweight patients showed higher ESRD risks than overweight patients. Weight loss >10% was associated with the fastest decline in renal function.
- Subjects
SOUTH Korea; OBESITY complications; CHRONIC kidney failure; BODY weight; AGE distribution; HYPOGLYCEMIC agents; LEANNESS; TYPE 2 diabetes; RISK assessment; NATIONAL health services; WEIGHT gain; COMPARATIVE studies; WAIST circumference; DESCRIPTIVE statistics; WEIGHT loss; DISEASE duration; BODY mass index; LONGITUDINAL method; DISEASE risk factors; DISEASE complications
- Publication
Nutrients, 2022, Vol 14, Issue 1, p154
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14010154