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- Title
Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?
- Authors
Spiga, Rosangela; Mannino, Gaia Chiara; Mancuso, Elettra; Averta, Carolina; Paone, Claudia; Rubino, Mariangela; Sciacqua, Angela; Succurro, Elena; Perticone, Francesco; Andreozzi, Francesco; Sesti, Giorgio
- Abstract
Magnesium (Mg2+) is an enzyme co-factor that plays a key role in many biochemical reactions, as well as in glucose metabolism. Clinical evidences have demonstrated that depletion of serum Mg2+ increases exponentially with the duration of type 2 diabetes mellitus (T2DM). Diabetes is associated with low Mg2+, and hypomagnesemia is associated with insulin resistance, inflammation, and increased risk for cardiovascular disease. In subjects at high risk of inflammation and insulin resistance, supplementation of Mg2+ alone ameliorates both phenotypes, slowing the development and progression of hepatic steatosis. We analyze the relationship between serum Mg2+ levels and the onset of T2DM in a large cohort of well-characterized adult white individuals participating in the CATAMERI study, who were reexamined after a mean follow-up of 5.6 ± 0.9 years. In our analysis we acquired a significant negative correlation between Mg2+ levels, fasting glucose, and 2h-post load glucose in subjects who underwent an OGTT. Moreover, Mg2+ levels correlated negatively with fasting insulin levels, and positively with the lipid profile. As for the detrimental effect of lower circulating Mg2+ levels, our data revealed a significant reduction of T2DM risk of about 20% for each 1 mg/dL increase of circulating Mg2+. The present results are consistent with the theory that Mg2+ supplementation could ameliorate insulin sensitivity reducing the risk to develop T2DM.
- Subjects
TYPE 2 diabetes risk factors; INFLAMMATION; INSULIN resistance risk factors; BLOOD sugar; CARDIOVASCULAR diseases risk factors; DIETARY supplements; HYPOMAGNESEMIA; MAGNESIUM; DESCRIPTIVE statistics; DISEASE complications
- Publication
Nutrients, 2019, Vol 11, Issue 10, p2460
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11102460