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- Title
Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation.
- Authors
Frühbeck, Gema; Catalán, Victoria; Rodríguez, Amaia; Ramírez, Beatriz; Becerril, Sara; Salvador, Javier; Colina, Inmaculada; Gómez-Ambrosi, Javier
- Abstract
Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = −0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk.
- Subjects
TYPE 2 diabetes risk factors; OBESITY; METABOLIC syndrome risk factors; OBESITY complications; ADIPOSE tissues; AMYLOID; BIOMARKERS; BLOOD sugar; CARDIOVASCULAR diseases risk factors; RISK assessment; LEPTIN; ADIPONECTIN; DIAGNOSIS
- Publication
Nutrients, 2019, Vol 11, Issue 2, p454
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11020454