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- Title
Streamlining the synthesis of amides using Nickel-based nanocatalysts.
- Authors
Gao, Jie; Ma, Rui; Poovan, Fairoosa; Zhang, Lan; Atia, Hanan; Kalevaru, Narayana V.; Sun, Wenjing; Wohlrab, Sebastian; Chusov, Denis A.; Wang, Ning; Jagadeesh, Rajenahally V.; Beller, Matthias
- Abstract
The synthesis of amides is a key technology for the preparation of fine and bulk chemicals in industry, as well as the manufacture of a plethora of daily life products. Furthermore, it constitutes a central bond-forming methodology for organic synthesis and provides the basis for the preparation of numerous biomolecules. Here, we present a robust methodology for amide synthesis compared to traditional amidation reactions: the reductive amidation of esters with nitro compounds under additives-free conditions. In the presence of a specific heterogeneous nickel-based catalyst a wide range of amides bearing different functional groups can be selectively prepared in a more step-economy way compared to previous syntheses. The potential value of this protocol is highlighted by the synthesis of drugs, as well as late-stage modifications of bioactive compounds. Based on control experiments, material characterizations, and DFT computations, we suggest metallic nickel and low-valent Ti-species to be crucial factors that makes this direct amide synthesis possible. The synthesis of amides is a key technology for the preparation of fine and bulk chemicals in industry. Here, the authors present the reductive amidation of esters with nitro compounds under additivesfree conditions as a robust methodology for amide synthesis.
- Subjects
NANOPARTICLES; AMIDES; ORGANIC synthesis; DRUG synthesis; CHEMICAL industry; HETEROGENEOUS catalysts; NITRO compounds
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-40614-1