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- Title
Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome.
- Authors
Meade, Maureen O.; Cook, Deborah J.; Guyatt, Gordon H.; Slutsky, Arthur S.; Arabi, Yaseen M.; Cooper, D. James; Davies, Andrew R.; Hand, Lori E.; Qi Zhou; Thabane, Lehana; Austin, Peggy; Lapinsky, Stephen; Baxter, Alan; Russell, James; Skrobik, Yoanna; Ronco, Juan J.; Stewart, Thomas E.
- Abstract
The article presents a discussion of research which compared an established low tidal-volume ventilation strategy with an experimental strategy based on the original open lung approach combining low tidal volume, lung recruitment maneuvers and high positive end expiratory pressure. The research involved 983 consecutive patients with acute lung injury and a ratio of arterial oxygen tension to inspired oxygen fraction not exceeding 250. Researchers found that for patients with acute lung injury and acute respiratory distress syndrome a multifaceted ventilation strategy designed to open the lung resulted in no significant difference in hospital mortality or barotrauma compared with a low tidal-volume strategy.
- Subjects
THERAPEUTICS research; LUNG diseases; LUNG injury treatment; MECHANICAL ventilators; ADULT respiratory distress syndrome; PULMONARY manifestations of general diseases; RESPIRATORY insufficiency
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 6, p637
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.299.6.637